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Blood culture is currently the reference standard for detecting bloodstream infection, a multistep process which may take one to several days. Here, we report a novel paradigm for earlier detection and the simultaneous identification of pathogens in spiked blood cultures by means of a metabolomic \u201cfingerprint\u201d of the volatile mixture outgassed by the organisms. The colorimetric sensor array provided significantly faster detection of positive blood cultures than a conventional blood culture system (12.1 h versus 14.9 h,<jats:italic>P<\/jats:italic>&lt; 0.001) while allowing for the identification of 18 bacterial species with 91.9% overall accuracy within 2 h of growth detection. The colorimetric sensor array also allowed for discrimination between unrelated strains of methicillin-resistant<jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>, indicating that the metabolomic fingerprint has the potential to track nosocomial transmissions. Altogether, the colorimetric sensor array is a promising tool that offers a new paradigm for diagnosing bloodstream infections.<\/jats:p>","DOI":"10.1128\/jcm.02377-13","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T03:25:55Z","timestamp":1386818755000},"page":"592-598","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":65,"title":["Colorimetric Sensor Array Allows Fast Detection and Simultaneous Identification of Sepsis-Causing Bacteria in Spiked Blood Culture"],"prefix":"10.1128","volume":"52","author":[{"given":"Sung H.","family":"Lim","sequence":"first","affiliation":[{"name":"Specific Technologies, Mountain View, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Mix","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Infectious Diseases Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Infectious Diseases Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Taba","sequence":"additional","affiliation":[{"name":"Specific Technologies, Mountain View, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indre","family":"Budvytiene","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Infectious Diseases Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders N.","family":"Berliner","sequence":"additional","affiliation":[{"name":"Specific Technologies, Mountain View, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Queralto","sequence":"additional","affiliation":[{"name":"Specific Technologies, Mountain View, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair S.","family":"Churi","sequence":"additional","affiliation":[{"name":"Specific Technologies, Mountain View, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Huang","sequence":"additional","affiliation":[{"name":"Specific Technologies, Mountain View, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Eiden","sequence":"additional","affiliation":[{"name":"Specific Technologies, Mountain View, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond A.","family":"Martino","sequence":"additional","affiliation":[{"name":"Specific Technologies, Mountain View, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Specific Technologies, Mountain View, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niaz","family":"Banaei","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Infectious Diseases Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA"},{"name":"Department of Medicine, Division of Infectious Diseases Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA"},{"name":"Clinical Microbiology Laboratory, Stanford University Medical Center, Palo Alto, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318169eda9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181cc4824"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00043-09"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00072-12"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","DOI":"10.1128\/9781555816728","volume-title":"Manual of clinical microbiology","author":"Versalovic J","year":"2011","unstructured":"VersalovicJCarrollKCFunkeGJorgensenJHLandryMLWarnockDW (ed). 2011. 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