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Rapid and inexpensive screening methods are utilized when molecular methods are not operationally feasible. In this multisite clinical trial, the utility of Bio-Rad's MRSA<jats:italic>Select<\/jats:italic>II was evaluated for MRSA identification from remnant nares and wound swabs. The prevalence of MRSA was 11.1% (<jats:italic>n<\/jats:italic>= 1,384) from nares samples and 18.1% (<jats:italic>n<\/jats:italic>= 842) from wound samples. MRSA<jats:italic>Select<\/jats:italic>II had an overall concordance of 95.4% (confidence interval [CI] = 94.5% to 96.2%) compared to a broth-enriched reference standard. Comparisons between results, stratified by examination times, exhibited a nonsignificant trend toward increased positivity at prolonged incubation times. Cefoxitin screening of colonies directly from MRSA<jats:italic>Select<\/jats:italic>II was 96.7% (95.8% to 97.3%) concordant compared to testing of colonies following broth enrichment. A comparison of MRSA<jats:italic>Select<\/jats:italic>and MRSA<jats:italic>Select<\/jats:italic>II revealed no statistical differences; however, the latter exhibited earlier positivity, greater selectivity, and more intense indicator staining, which resulted in facilitated differentiation of positive results. MRSA<jats:italic>Select<\/jats:italic>II agar is a simple, rapid, and robust method to routinely screen patients for MRSA colonization without the need for additional testing.<\/jats:p>","DOI":"10.1128\/jcm.02410-15","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T03:53:23Z","timestamp":1447905203000},"page":"305-311","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Multicenter Evaluation of MRSA<i>Select<\/i>II Chromogenic Agar for Identification of Methicillin-Resistant Staphylococcus aureus from Wound and Nasal Specimens"],"prefix":"10.1128","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1377-4438","authenticated-orcid":false,"given":"Diana R.","family":"Hernandez","sequence":"first","affiliation":[{"name":"Geisinger Health System, Danville, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duane W.","family":"Newton","sequence":"additional","affiliation":[{"name":"University of Michigan Health System, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan A.","family":"Ledeboer","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin, Milwaukee, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4111-048X","authenticated-orcid":false,"given":"Blake","family":"Buchan","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin, Milwaukee, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Young","sequence":"additional","affiliation":[{"name":"University of Michigan Health System, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew E.","family":"Clark","sequence":"additional","affiliation":[{"name":"University of Arizona, Tucson, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Connoly","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin, Milwaukee, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna M.","family":"Wolk","sequence":"additional","affiliation":[{"name":"Geisinger Health System, Danville, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5219.124"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/646432"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0195-6701(86)90064-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1080\/19739478.1994.12314799","article-title":"Epidemiology of staphylococcal infections\u2013a European perspective","volume":"6","author":"Vandenbroucke-Grauls C","year":"1994","unstructured":"Vandenbroucke-Grauls C. 1994. 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