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They are based on a combination of MIC values, pharmacokinetic\/pharmacodynamic values, and clinical outcome data. For many fungus-antifungal combinations, these data might never be available. For these combinations, epidemiological cutoff values (ECVs) provide a methodology for categorizing isolates as either wild type (WT) or non-WT. In this review, we define ECVs, explain how they are generated using the CLSI methodology in standard M57, and describe how they can be used in clinical practice.<\/jats:p>","DOI":"10.1128\/jcm.02416-16","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T20:50:18Z","timestamp":1487191818000},"page":"1262-1268","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":78,"title":["Establishment and Use of Epidemiological Cutoff Values for Molds and Yeasts by Use of the Clinical and Laboratory Standards Institute M57 Standard"],"prefix":"10.1128","volume":"55","author":[{"given":"Shawn R.","family":"Lockhart","sequence":"first","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A.","family":"Ghannoum","sequence":"additional","affiliation":[{"name":"Center for Medical Mycology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara D.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and International Health, Departments of Medicine and Pathology, Duke University, Durham, North Carolina, USA"},{"name":"Clinical Microbiology Laboratory, Departments of Medicine and Pathology, Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"CLSI supplement M57","author":"Clinical and Laboratory Standards Institute","year":"2016","unstructured":"Clinical and Laboratory Standards Institute. 2016. 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