{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:45:27Z","timestamp":1770745527051,"version":"3.49.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2021,5,19]]},"abstract":"<jats:p>Accurate and early susceptibility results could reduce overuse of broad-spectrum antibiotics for empirical treatment of bacteremia. Direct disk diffusion testing (dDD) using nonstandardized inocula directly from blood cultures could facilitate earlier narrowing of antibiotics.<\/jats:p>","DOI":"10.1128\/jcm.02445-20","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T12:41:33Z","timestamp":1615466493000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Predictive Value of Direct Disk Diffusion Testing from Positive Blood Cultures in a Children\u2019s Hospital and Its Utility in Antimicrobial Stewardship"],"prefix":"10.1128","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-7379","authenticated-orcid":true,"given":"Timothy J.","family":"Savage","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Boston Children\u2019s Hospital, Boston, Massachusetts, USA"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Rao","sequence":"additional","affiliation":[{"name":"Precision Vaccines Program, Division of Infectious Diseases, Boston Children\u2019s Hospital, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Joerger","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Al","family":"Ozonoff","sequence":"additional","affiliation":[{"name":"Precision Vaccines Program, Division of Infectious Diseases, Boston Children\u2019s Hospital, Boston, Massachusetts, USA"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J.","family":"McAdam","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Sandora","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Boston Children\u2019s Hospital, Boston, Massachusetts, USA"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.15620\/cdc:82532"},{"key":"e_1_3_3_3_2","unstructured":"Interagency Coordination Group on Antimicrobial Resistance (IACG). 2019. No time to wait: securing the future from drug-resistant infections. World Health Organization Geneva Switzerland. https:\/\/www.who.int\/antimicrobial-resistance\/interagency-coordination-group\/final-report\/en\/."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.1938"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ447"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02264-16"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1373\/jalm.2018.027409"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0327-x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00360-20"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy308"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01400-19"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00095-17"},{"key":"e_1_3_3_13_2","volume-title":"Microbiology laboratory","author":"Esser VM","year":"1969","unstructured":"Esser VM, Elefson DONE. 1969. Microbiology laboratory, Department of Pathology, Mercy Hospital, Des Moines, Iowa."},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46937-0"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00437-18"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000259"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2017.94"},{"key":"e_1_3_3_18_2","volume-title":"Performance standards for antimicrobial susceptibility testing, supplement M100","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2017","unstructured":"Clinical and Laboratory Standards Institute (CLSI). 2017. Performance standards for antimicrobial susceptibility testing, supplement M100, 27th edition. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"27"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.05.007"},{"key":"e_1_3_3_20_2","first-page":"1","article-title":"Recommendations for preventing the spread of vancomycin resistance. Recommendations of the Hospital Infection Control Practices Advisory Committee (HICPAC)","volume":"44","author":"Larson EL","year":"1995","unstructured":"Larson EL, Mayhall CG, Nichols RL, Russell BJ, Adams AB, Fleming DW. 1995. Recommendations for preventing the spread of vancomycin resistance. Recommendations of the Hospital Infection Control Practices Advisory Committee (HICPAC). MMWR Recomm Rep 44:1\u201313.","journal-title":"MMWR Recomm Rep"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piz064"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir073"},{"key":"e_1_3_3_23_2","article-title":"Guideline for the management of fever and neutropenia in children with cancer and\/or undergoing hematopoietic stem-cell transplantation","author":"Children\u2019s Oncology Group","year":"2015","unstructured":"Children\u2019s Oncology Group. 2015. Guideline for the management of fever and neutropenia in children with cancer and\/or undergoing hematopoietic stem-cell transplantation. Children\u2019s Oncology Group, Monrovia, CA. http:\/\/childrensoncologygroup.org\/downloads\/COG_SC_FN_Guideline_Document.pdf.","journal-title":"Children\u2019s Oncology Group, Monrovia, CA"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/598244"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2014.10.005"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2013.02.009"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01166-17"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.02445-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.02445-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T13:03:04Z","timestamp":1646485384000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.02445-20"}},"subtitle":[],"editor":[{"given":"Patricia J.","family":"Simner","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,5,19]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,5,19]]}},"alternative-id":["10.1128\/JCM.02445-20"],"URL":"https:\/\/doi.org\/10.1128\/jcm.02445-20","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,19]]},"assertion":[{"value":"2020-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02445-20"}}