{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:53:52Z","timestamp":1782456832103,"version":"3.54.5"},"reference-count":11,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Repeat\n Chlamydia trachomatis<\/jats:named-content>\n detection frequently occurs within months after\n C. trachomatis<\/jats:named-content>\n infection treatment. The origins of such infection (persistence versus reinfection from untreated or new partners) are varied and difficult to determine.\n C. trachomatis<\/jats:named-content>\n strains can be differentiated by sequencing the\n ompA<\/jats:italic>\n gene encoding the outer membrane protein A (OmpA). We used OmpA genotyping to investigate the epidemiology of repeat\n C. trachomatis<\/jats:named-content>\n detection after treatment in\n C. trachomatis<\/jats:named-content>\n -infected subjects seen at a sexually transmitted diseases clinic. Subjects were enrolled, tested for\n C. trachomatis<\/jats:named-content>\n , treated with azithromycin, and scheduled for a 6-month follow-up for repeat\n C. trachomatis<\/jats:named-content>\n testing. OmpA genotyping was performed on\n C. trachomatis<\/jats:named-content>\n -positive urogenital specimens obtained from patients at enrollment and follow-up. The enrollment visit OmpA genotypes for\n C. trachomatis<\/jats:named-content>\n were determined for 162 subjects (92% female, 94% African American).\n C. trachomatis<\/jats:named-content>\n was detected at follow-up in 39 subjects (24%). The OmpA genotype distribution at enrollment did not differ in those with versus those without repeat\n C. trachomatis<\/jats:named-content>\n detection. Of the 35 subjects with\n C. trachomatis<\/jats:named-content>\n strains genotyped at enrollment and follow-up, 7 (20%) had the same\n ompA<\/jats:italic>\n sequence at both visits, while 28 (80%) had discordant sequences. A new sexual partner was reported more often in subjects with discordant\n C. trachomatis<\/jats:named-content>\n strains than in those with concordant strains (13 [46%] versus 1 [14%];\n P<\/jats:italic>\n = 0.195). Half of the subjects with discordant\n C. trachomatis<\/jats:named-content>\n strains who reported sexual activity since treatment denied a new sexual partner; 62% of these subjects reported that their partner was treated. Our study demonstrates that most repeat\n C. trachomatis<\/jats:named-content>\n detections after treatment were new infections with a different\n C. trachomatis<\/jats:named-content>\n strain rather than reinfection with the same strain. OmpA genotyping can be a useful tool in understanding the origins of repeat\n C. trachomatis<\/jats:named-content>\n detection after treatment.\n <\/jats:p>","DOI":"10.1128\/jcm.02483-14","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T02:37:48Z","timestamp":1417660668000},"page":"546-549","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Investigating the Epidemiology of Repeat Chlamydia trachomatis Detection after Treatment by Using C. trachomatis OmpA Genotyping"],"prefix":"10.1128","volume":"53","author":[{"given":"Richa","family":"Kapil","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christen G.","family":"Press","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Lisa","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LaDraka","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Geisler","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3181a2a933"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182246a83"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e31817247b2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-200304000-00016"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2008.030825"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81812-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/159.4.661"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/173.4.950"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/648734"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.5.1225"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/315778"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.02483-14","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.02483-14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T12:07:03Z","timestamp":1646482023000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.02483-14"}},"subtitle":[],"editor":[{"given":"P.","family":"Bourbeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1128\/JCM.02483-14"],"URL":"https:\/\/doi.org\/10.1128\/jcm.02483-14","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"2014-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}