{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:54:35Z","timestamp":1761580475636},"reference-count":45,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Meningococcal disease is characterized by cyclic fluctuations in incidence, serogroup distribution, and antigenic profiles. In greater Sa\u0303o Paulo, Brazil, there has been a constant increase in the incidence of serogroup C meningococcal disease since the late 1980s. To gain an understanding of changes in serogroup C meningococcal disease over three decades in greater Sa\u0303o Paulo, Brazil, 1,059 invasive\n            <jats:italic>Neisseria meningitidis<\/jats:italic>\n            serogroup C isolates from 1976 and 2005 were analyzed. Three major clone complexes, sequence type (ST)-11, ST-8, and ST-103, were identified by multilocus sequence typing, and the isolates were characterized by serotyping and 16S rRNA typing. During the 30-year period, there were two major antigenic replacements: from 2a:P1.(5,2) to 2b:P1.3 and subsequently to 23:P1.14-6. All strains of clone ST-103 were characterized as serotype 23 and serosubtype P1.14-6. The origin of 23:P1.14-6 ST-103 complex strains is unknown, but efforts are needed to monitor its spread and define its virulence. The antigenic replacements we observed likely represent a mechanism to sustain meningococcal disease in the population as immunity to circulating strains accumulated.\n          <\/jats:p>","DOI":"10.1128\/jcm.02510-06","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T01:46:29Z","timestamp":1172108789000},"page":"1266-1273","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["Clonal Distribution of Invasive\n            <i>Neisseria meningitidis<\/i>\n            Serogroup C Strains Circulating from 1976 to 2005 in Greater Sa\u0303o Paulo, Brazil"],"prefix":"10.1128","volume":"45","author":[{"given":"Ana Paula Silva","family":"de Lemos","sequence":"first","affiliation":[{"name":"Division of Medical Biology, Bacteriology Department, Adolfo Lutz Institute, Sa\u0303o Paulo 01246-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa Ykuko","family":"Yara","sequence":"additional","affiliation":[{"name":"Division of Medical Biology, Bacteriology Department, Adolfo Lutz Institute, Sa\u0303o Paulo 01246-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Ceci\u0301lia Outeiro","family":"Gorla","sequence":"additional","affiliation":[{"name":"Division of Medical Biology, Bacteriology Department, Adolfo Lutz Institute, Sa\u0303o Paulo 01246-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Vaneide","family":"de Paiva","sequence":"additional","affiliation":[{"name":"Division of Medical Biology, Bacteriology Department, Adolfo Lutz Institute, Sa\u0303o Paulo 01246-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Lambert","family":"de Souza","sequence":"additional","affiliation":[{"name":"Division of Medical Biology, Bacteriology Department, Adolfo Lutz Institute, Sa\u0303o Paulo 01246-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Ine\u0302s Cappelletti","family":"Gonc\u0327alves","sequence":"additional","affiliation":[{"name":"Center for Epidemiological Surveillance Prof. Alexandre Vranjac, Sa\u0303o Paulo 01246-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samanta Cristine Grassi","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Division of Medical Biology, Bacteriology Department, Adolfo Lutz Institute, Sa\u0303o Paulo 01246-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria Regina Feitas","family":"do Valle","sequence":"additional","affiliation":[{"name":"Division of Medical Biology, Bacteriology Department, Adolfo Lutz Institute, Sa\u0303o Paulo 01246-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio Tavares","family":"Sacchi","sequence":"additional","affiliation":[{"name":"Division of Medical Biology, Immunology Department, Adolfo Lutz Institute, Sa\u0303o Paulo 01246-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0812.020081"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-51-12-1102"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1139\/w97-121"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.169.6.2781-2792.1987"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.55.6.1503-1512.1987"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.4.867"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1998.tb01379.x"},{"key":"e_1_3_2_9_2","unstructured":"O livro da meningite: uma doen\u00e7a sob a luz da cidade. 2004"},{"key":"e_1_3_2_10_2","first-page":"345","volume":"79","year":"1992","unstructured":"Frosch, M., and T. 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