{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:03:54Z","timestamp":1791187434265,"version":"4.1.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Antibiotic treatment is not required in cases of\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    gastroenteritis but is essential in cases of enteric fever or invasive salmonellosis or in immunocompromised patients. Although fluoroquinolones and extended-spectrum cephalosporins are the drugs of choice to treat invasive\n                    <jats:italic>Salmonella<\/jats:italic>\n                    , resistance to these antibiotics is increasing worldwide. During the period 2000 to 2003, 90\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    serovar Virchow poultry and poultry product isolates and 11 serovar Virchow human isolates were found to produce an extended-spectrum \u03b2-lactamase, CTX-M-2, concomitantly with a TEM-1 \u03b2-lactamase. The\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>CTX-M-2<\/jats:sub>\n                    gene was located on a large conjugative plasmid (&gt;100 kb). Pulsed-field gel electrophoresis indicated a clonal relationship between the poultry and human isolates. All these isolates displayed additional resistance to trimethoprim-sulfamethoxazole and tetracycline as well as a reduced susceptibility to ciprofloxacin (MICs of between 0.5 and 1 \u03bcg\/ml). CTX-M-2-producing\n                    <jats:italic>Salmonella<\/jats:italic>\n                    with a reduced susceptibility to fluoroquinolones constitutes a major concern, since such strains could disseminate on a large scale and jeopardize classical antibiotic therapy in immunocompromised patients.\n                  <\/jats:p>","DOI":"10.1128\/jcm.02549-05","type":"journal-article","created":{"date-parts":[[2006,8,4]],"date-time":"2006-08-04T21:54:18Z","timestamp":1154728458000},"page":"2897-2903","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":131,"title":["Clonal Emergence of Extended-Spectrum \u03b2-Lactamase (CTX-M-2)-Producing\n                    <i>Salmonella enterica<\/i>\n                    Serovar Virchow Isolates with Reduced Susceptibilities to Ciprofloxacin among Poultry and Humans in Belgium and France (2000 to 2003)"],"prefix":"10.1128","volume":"44","author":[{"given":"Sophie","family":"Bertrand","sequence":"first","affiliation":[{"name":"National Reference Centre for Salmonella and Shigella"},{"name":"Bacteriology Division"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc\u0327ois-Xavier","family":"Weill","sequence":"additional","affiliation":[{"name":"Centre National de Re\u0301fe\u0301rence des Salmonella, Unite\u0301 de Biodiversite\u0301 des Bacte\u0301ries Pathoge\u0300nes Emergentes, Institut Pasteur, INSERM U389, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Cloeckaert","sequence":"additional","affiliation":[{"name":"Unite\u0301 BioAgresseurs, Sante\u0301 et Environnement, Institut National de la Recherche Agronomique, 37380 Nouzilly, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Vrints","sequence":"additional","affiliation":[{"name":"Bacteriology Division"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Mairiaux","sequence":"additional","affiliation":[{"name":"Bureau of Quality Assurance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Praud","sequence":"additional","affiliation":[{"name":"Unite\u0301 BioAgresseurs, Sante\u0301 et Environnement, Institut National de la Recherche Agronomique, 37380 Nouzilly, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katlijne","family":"Dierick","sequence":"additional","affiliation":[{"name":"Bacteriology Division"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Wildemauve","sequence":"additional","affiliation":[{"name":"Phage Typing Centre, Department Pasteur Institute, Scientific Institute of Public Health, 14 Wytsman Street, B-1050 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Godard","sequence":"additional","affiliation":[{"name":"Phage Typing Centre, Department Pasteur Institute, Scientific Institute of Public Health, 14 Wytsman Street, B-1050 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Butaye","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, CODA-CERVA-VAR, Groeselenberg 99, 1180 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hein","family":"Imberechts","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, CODA-CERVA-VAR, Groeselenberg 99, 1180 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick A. D.","family":"Grimont","sequence":"additional","affiliation":[{"name":"Centre National de Re\u0301fe\u0301rence des Salmonella, Unite\u0301 de Biodiversite\u0301 des Bacte\u0301ries Pathoge\u0300nes Emergentes, Institut Pasteur, INSERM U389, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Collard","sequence":"additional","affiliation":[{"name":"National Reference Centre for Salmonella and Shigella"},{"name":"Bacteriology Division"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.2.827-829.2003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/10766290260469543"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01704610"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.1.1-14.2004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.6.2373-2374.2001"},{"key":"e_1_3_2_7_2","first-page":"1455","volume":"9","year":"2003","unstructured":"Casin, I., J. 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