{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:39:06Z","timestamp":1791895146278,"version":"4.3.4"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Candidemia is often a life-threatening infection, with highly variable incidence among countries. We conducted a nationwide study of candidemia in Iceland from 2000 to 2011, in order to determine recent trends in incidence rates, fungal species distribution, antifungal susceptibility patterns, and concurrent antifungal consumption. A total of 208 infection episodes in 199 patients were identified. The average incidence during the 12 years was 5.7 cases\/100,000 population\/year, which was significantly higher than that from 1990 to 1999 (4.3\/100,000\/year;\n            <jats:italic>P<\/jats:italic>\n            = 0.02). A significant reduction in the use of blood cultures was noted in the last 3 years of the study, coinciding with the economic crisis in the country (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). Age-specific incidence rates were highest among patients at the extremes of age, 20.7\/100,000 for &lt;1 year of age and 18.1\/100,000 for &gt;60 years, and varied by gender. Age-specific incidence among males &gt;80 years old was 28.6\/100,000\/year, and it was 8.3\/100,000\/year for females in this age group (\n            <jats:italic>P<\/jats:italic>\n            = 0.028). The 30-day survival rate among adult patients remained unchanged compared to that from 1990 to 1999 (70.4% versus 69.5%,\n            <jats:italic>P<\/jats:italic>\n            = 0.97).\n            <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n            was the predominant species (56%), followed by\n            <jats:named-content content-type=\"genus-species\">C. glabrata<\/jats:named-content>\n            (16%) and\n            <jats:named-content content-type=\"genus-species\">C. tropicalis<\/jats:named-content>\n            (13%). The species distribution remained stable compared to that from previous decades. Fluconazole use increased 2.4-fold from 2000 to 2011, with no increase in resistance. In summary, the incidence of candidemia in Iceland has continued to increase but may have reached a steady state, and no increase in antifungal drug resistance has been noted. Decreased use of blood cultures toward the end of the study may have influenced detection rates.\n          <\/jats:p>","DOI":"10.1128\/jcm.02566-12","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T01:34:56Z","timestamp":1356572096000},"page":"841-848","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":80,"title":["Nationwide Study of Candidemia, Antifungal Use, and Antifungal Drug Resistance in Iceland, 2000 to 2011"],"prefix":"10.1128","volume":"51","author":[{"given":"Lena Ros","family":"Asmundsdottir","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology, Landspitali University Hospital, Baronsstig, Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga","family":"Erlendsdottir","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Landspitali University Hospital, Baronsstig, Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Gottfredsson","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Landspitali University Hospital, Fossvogi, Reykjavik, Iceland"},{"name":"University of Iceland, Faculty of Medicine, Vatnsmyrarvegi, Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/378745"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/502581"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis697"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.4.1298-1302.2002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/313450"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.4.1829-1835.2005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47239-0"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0908.030069"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-312"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00029-06"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.01.002"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01811-10"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-0973-8"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.02.001"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1470-9465.2004.t01-1-00844.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00409-07"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-004-1103-y"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01398-10"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.9.3489-3492.2002"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1086\/589298"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02840.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2010.09.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2011.03.002"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2011.01.004"},{"key":"e_1_3_2_27_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts; informational supplement","author":"Clinical and Laboratory Standards Institute","year":"2008","unstructured":"Clinical and Laboratory Standards Institute. 2008. 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