{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:24:36Z","timestamp":1771457076094,"version":"3.50.1"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The susceptibilities to antimicrobial agents of and distributions of antiseptic resistance genes in methicillin-resistant\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            (MRSA) strains isolated between 1999 and 2004 in Japan were examined. The data of MRSA strains that are causative agents of impetigo and staphylococcal scalded skin syndrome (SSSS) were compared with those of MRSA strains isolated from patients with other diseases. The susceptibilities to antiseptic agents in MRSA isolates from patients with impetigo and SSSS were higher than those in MRSA isolates from patients with other diseases. The distribution of the\n            <jats:italic>qacA\/B<\/jats:italic>\n            genes in MRSA strains isolated from patients with impetigo and SSSS (1.3%, 1\/76) was remarkably lower than that in MRSA strains isolated from patients with other diseases (45.9%, 95\/207). Epidemiologic typings of staphylococcal cassette chromosome\n            <jats:italic>mec<\/jats:italic>\n            (SCC\n            <jats:italic>mec<\/jats:italic>\n            ) and pulsed-field gel electrophoresis (PFGE) showed that MRSA strains isolated from patients with impetigo and SSSS had type IV SCC\n            <jats:italic>mec<\/jats:italic>\n            (75\/76), except for one strain, and 64.5% (49\/76) of the strains had different PFGE types. In addition, the patterns of restriction digestion of all tested\n            <jats:italic>qacA\/B<\/jats:italic>\n            plasmid in MRSA isolates having different PFGE types were identical. The results showed that a specific MRSA clone carrying\n            <jats:italic>qacA\/B<\/jats:italic>\n            was not prevalent, but\n            <jats:italic>qacA\/B<\/jats:italic>\n            was spread among health care-associated MRSA strains. Therefore, it was concluded that the lower distribution rate of\n            <jats:italic>qacA\/B<\/jats:italic>\n            resulted in higher susceptibilities to cationic antiseptic agents in MRSA isolated from patients with impetigo and SSSS.\n          <\/jats:p>","DOI":"10.1128\/jcm.02690-05","type":"journal-article","created":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T10:58:07Z","timestamp":1149677887000},"page":"2119-2125","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":90,"title":["Antimicrobial Agent of Susceptibilities and Antiseptic Resistance Gene Distribution among Methicillin-Resistant\n            <i>Staphylococcus aureus<\/i>\n            Isolates from Patients with Impetigo and Staphylococcal Scalded Skin Syndrome"],"prefix":"10.1128","volume":"44","author":[{"given":"Norihisa","family":"Noguchi","sequence":"first","affiliation":[{"name":"Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemasa","family":"Nakaminami","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuko","family":"Nishijima","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kori Hospital, Kansai Medical University, 8-45 Korihondori, Neyagawa, Osaka 572-8551, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu, Mie 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromu","family":"So","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kori Hospital, Kansai Medical University, 8-45 Korihondori, Neyagawa, Osaka 572-8551, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Sasatsu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"S1","volume":"9","year":"2003","unstructured":"Alam, M. 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