{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:49:21Z","timestamp":1791071361032,"version":"4.1.0"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Candida africana<\/jats:named-content>\n was previously proposed as a new species within the\n Candida albicans<\/jats:named-content>\n species complex, together with\n C. albicans<\/jats:named-content>\n and\n C. dubliniensis<\/jats:named-content>\n , although further phylogenetic analyses better support its status as an unusual variant within\n C. albicans<\/jats:named-content>\n . Here we show that\n C. africana<\/jats:named-content>\n can be distinguished from\n C. albicans<\/jats:named-content>\n and\n C. dubliniensis<\/jats:named-content>\n by pyrosequencing of a short region of ITS2, and we have evaluated its occurrence in clinical samples by pyrosequencing all presumptive isolates of\n C. albicans<\/jats:named-content>\n submitted to the Mycology Reference Laboratory over a 9-month period. The\n C. albicans<\/jats:named-content>\n complex constituted 826\/1,839 (44.9%) of yeast isolates received over the study period and included 783 isolates of\n C. albicans<\/jats:named-content>\n , 28 isolates of\n C. dubliniensis<\/jats:named-content>\n , and 15 isolates of\n C. africana<\/jats:named-content>\n . In agreement with previous reports,\n C. africana<\/jats:named-content>\n was isolated exclusively from genital specimens, in women in the 18-to-35-year age group. Indeed,\n C. africana<\/jats:named-content>\n constituted 15\/251 (6%) of \u201c\n C. albicans<\/jats:named-content>\n \u201d isolates from female genital specimens during the study period.\n C. africana<\/jats:named-content>\n isolates were germ tube positive, grew significantly more slowly than\n C. albicans<\/jats:named-content>\n and\n C. dubliniensis<\/jats:named-content>\n on conventional mycological media, could be distinguished from the other members of the\n C. albicans<\/jats:named-content>\n complex by appearance on chromogenic agar, and were incapable of forming chlamydospores. Here we present the detailed evaluation of epidemiological, phenotypic, and clinical features and antifungal susceptibility profiles of United Kingdom isolates of\n C. africana<\/jats:named-content>\n . Furthermore, we demonstrate that\n C. africana<\/jats:named-content>\n is significantly less pathogenic than\n C. albicans<\/jats:named-content>\n and\n C. dubliniensis<\/jats:named-content>\n in the\n Galleria mellonella<\/jats:named-content>\n insect systemic infection model.\n <\/jats:p>","DOI":"10.1128\/jcm.02816-12","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T04:55:40Z","timestamp":1357793740000},"page":"967-972","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":85,"title":["Epidemiology, Antifungal Susceptibility, and Pathogenicity of Candida africana Isolates from the United Kingdom"],"prefix":"10.1128","volume":"51","author":[{"given":"Andrew M.","family":"Borman","sequence":"first","affiliation":[{"name":"UK National Mycology Reference Laboratory (MRL), Health Protection Agency South-West, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Szekely","sequence":"additional","affiliation":[{"name":"UK National Mycology Reference Laboratory (MRL), Health Protection Agency South-West, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chistopher J.","family":"Linton","sequence":"additional","affiliation":[{"name":"UK National Mycology Reference Laboratory (MRL), Health Protection Agency South-West, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Palmer","sequence":"additional","affiliation":[{"name":"UK National Mycology Reference Laboratory (MRL), Health Protection Agency South-West, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillipa","family":"Brown","sequence":"additional","affiliation":[{"name":"UK National Mycology Reference Laboratory (MRL), Health Protection Agency South-West, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"UK National Mycology Reference Laboratory (MRL), Health Protection Agency South-West, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"9","article-title":"Invasive Candida infections: the changing epidemiology","volume":"18","author":"Marr KA","year":"2004","unstructured":"MarrKA. 2004. 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