{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:54:27Z","timestamp":1791172467911,"version":"4.1.0"},"reference-count":50,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Norovirus and rotavirus are the two most important causes of acute gastroenteritis in children worldwide. Both norovirus and rotavirus recognize human histo-blood group antigens (HBGAs), and multiple binding patterns for HBGAs have been reported. To explore the role of HBGAs in host susceptibility to norovirus and rotavirus, we conducted a cross-sectional study in children hospitalized with diarrhea in northern Vietnam from September 2010 through September 2012. Of 260 children with paired stool and saliva samples, 158 (61%) were classified as HBGA secretors (Le\n                    <jats:sup>a\u2212b+<\/jats:sup>\n                    ), 31 (12%) were nonsecretors (Le\n                    <jats:sup>a+b\u2212<\/jats:sup>\n                    ), and 71 (27%) were partial secretors (Le\n                    <jats:sup>a+b+<\/jats:sup>\n                    ). Norovirus was detected in 50 patients (19%), with viral genotypes GII.3 (\n                    <jats:italic>n<\/jats:italic>\n                    = 28) and GII.4 (\n                    <jats:italic>n<\/jats:italic>\n                    = 22) being the most common. All children infected with norovirus strains of genotype GII.4 were either HBGA secretors or partial secretors. Of the 28 GII.3 cases, 12 involved HBGA secretors, 11 partial secretors, and 5 nonsecretors. A total of 85 children tested positive for rotavirus, 74 of whom were infected with genotype P[8], 5 with P[4], and 6 with P[6]; all were HBGA secretors or partial secretors. This is the first epidemiological study demonstrating in a population that HBGA phenotype is a key susceptibility factor for both norovirus and rotavirus infections in children.\n                  <\/jats:p>","DOI":"10.1128\/jcm.02927-13","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T01:02:33Z","timestamp":1392253353000},"page":"1366-1374","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":109,"title":["Association between Norovirus and Rotavirus Infection and Histo-Blood Group Antigen Types in Vietnamese Children"],"prefix":"10.1128","volume":"52","author":[{"given":"Nguyen Van","family":"Trang","sequence":"first","affiliation":[{"name":"National Institute of Hygiene and Epidemiology, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hau ThiBich","family":"Vu","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhung ThiHong","family":"Le","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengwei","family":"Huang","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dang Duc","family":"Anh","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-07"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804575"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1408.071114"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.12.092"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.7.5.14819"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-9"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-1945-3"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182a5f5b6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-013-1708-5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00979-12"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2005.04.004"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm860"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis514"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.23.12562-12571.2003"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002152"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00246-11"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4143-1_33"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-006-5435-y"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05507-11"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10996"},{"key":"e_1_3_2_22_2","volume-title":"Results of the Vietnam household living standards survey 2010","author":"General Statistics Office of Vietnam","year":"2011","unstructured":"General Statistics Office of Vietnam. 2011. 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