{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:28:43Z","timestamp":1790875723348,"version":"4.1.0"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Lyme disease is transmitted by the bite of certain\n            <jats:named-content content-type=\"genus-species\">Ixodes<\/jats:named-content>\n            ticks, which can also transmit\n            <jats:named-content content-type=\"genus-species\">Anaplasma phagocytophilum<\/jats:named-content>\n            , the cause of human granulocytic anaplasmosis (HGA). Although culture can be used to identify patients infected with\n            <jats:named-content content-type=\"genus-species\">A. phagocytophilum<\/jats:named-content>\n            and is the microbiologic gold standard, few studies have evaluated culture-confirmed patients with HGA. We conducted a prospective study in which blood culture was used to detect HGA infection in patients with a compatible clinical illness. Early Lyme disease was defined by the presence of erythema migrans. The epidemiologic, clinical, and laboratory features of 44 patients with culture-confirmed HGA were compared with those of a convenience sample of 62 patients with early Lyme disease. Coinfected patients were excluded. Patients with HGA had more symptoms (\n            <jats:italic>P<\/jats:italic>\n            = 0.003) and had a higher body temperature on presentation (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001) than patients with early Lyme disease. HGA patients were also more likely to have a headache, dizziness, myalgias, abdominal pain, anorexia, leukopenia, lymphopenia, thrombocytopenia, or elevated liver enzymes. A direct correlation between the number of symptoms and the duration of illness at time of presentation (rho = 0.389,\n            <jats:italic>P<\/jats:italic>\n            = 0.009) was observed for HGA patients but not for patients with Lyme disease. In conclusion, although there are overlapping features, culture-confirmed HGA is a more severe illness than early Lyme disease.\n          <\/jats:p>","DOI":"10.1128\/jcm.02929-12","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T04:55:40Z","timestamp":1357793740000},"page":"954-958","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["Differences and Similarities between Culture-Confirmed Human Granulocytic Anaplasmosis and Early Lyme Disease"],"prefix":"10.1128","volume":"51","author":[{"given":"Gary P.","family":"Wormser","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Aguero-Rosenfeld","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Nowakowski","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Nadelman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Holmgren","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"McKenna","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Bittker","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois","family":"Zentmaier","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionysios","family":"Liveris","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold W.","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60103-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/518146"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1374.042"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2011.09.008"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.7.769"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/153036602321653815"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199601253340401"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.2.635-638.2000"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.4.1648-1650.2000"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/323424"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/324490"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis852"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/515000"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/313532"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/107.2.142"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91475-0"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200878"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530450047031"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1103.040599"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1705.101334"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.02929-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.02929-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T11:36:09Z","timestamp":1646480169000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.02929-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1128\/JCM.02929-12"],"URL":"https:\/\/doi.org\/10.1128\/jcm.02929-12","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"2012-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}