{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:56:06Z","timestamp":1791352566167,"version":"4.3.1"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            To assess the clinical utility of replacing microbial culture for\n            <jats:named-content content-type=\"genus-species\">Neisseria gonorrhoeae<\/jats:named-content>\n            with a nucleic acid amplification test (NAAT), we compared\n            <jats:named-content content-type=\"genus-species\">N. gonorrhoeae<\/jats:named-content>\n            culture with the cobas 4800 CT\/NG test for 18,247 urogenital and 666 nongenital samples. For urogenital specimens, the sensitivity, specificity, and positive and negative predictive values of the cobas\n            <jats:named-content content-type=\"genus-species\">N. gonorrhoeae<\/jats:named-content>\n            PCR were 98.7%, 100%, 95.6%, and 100%, respectively, and for nongenital specimens, the values were 100%, 99.8%, 92.9%, and 100%, respectively. In our test population, 37% (10,185) of patients tested over the study period were screened for\n            <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n            by PCR but were not screened for gonorrhea by culture. Of these, 43 were\n            <jats:named-content content-type=\"genus-species\">N. gonorrhoeae<\/jats:named-content>\n            positive by PCR and therefore went undiagnosed. The cobas 4800 CT\/NG test diagnosed 33% (\n            <jats:italic>n<\/jats:italic>\n            = 30) more urogenital and 25% (\n            <jats:italic>n<\/jats:italic>\n            = 3) more rectal gonorrhea infections than culture and, based on the above performance indicators, does not require supplementary testing for urogenital or rectal specimens. The ability to test noninvasive specimens (such as urine and self-taken vulvovaginal swabs) for\n            <jats:named-content content-type=\"genus-species\">N. gonorrhoeae<\/jats:named-content>\n            will enable more patients to be screened for infection, thus offering significant positive public health benefits.\n          <\/jats:p>","DOI":"10.1128\/jcm.03223-12","type":"journal-article","created":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T02:51:57Z","timestamp":1362624717000},"page":"1505-1509","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["Comparison of the cobas 4800 CT\/NG Test with Culture for Detecting Neisseria gonorrhoeae in Genital and Nongenital Specimens in a Low-Prevalence Population in New Zealand"],"prefix":"10.1128","volume":"51","author":[{"given":"Collette","family":"Bromhead","sequence":"first","affiliation":[{"name":"Aotea Pathology Ltd., Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Miller","sequence":"additional","affiliation":[{"name":"Aotea Pathology Ltd., Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Jones","sequence":"additional","affiliation":[{"name":"Aotea Pathology Ltd., Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Whiley","sequence":"additional","affiliation":[{"name":"Queensland Paediatric Infectious Diseases Laboratory, Queensland Children's Medical Research Institute, The University of Queensland &amp; SASVRC, Royal Children's Hospital, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Recommendations for Chlamydia testing in New Zealand.","author":"New Zealand Ministry of Health","year":"2008","unstructured":"New Zealand Ministry of Health. 2008. Recommendations for Chlamydia testing in New Zealand. New Zealand Ministry of Health, Wellington, New Zealand."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.2.386-390.1999"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.2.835-837.2003"},{"key":"e_1_3_2_5_2","volume-title":"Sexually transmitted infections in New Zealand: annual surveillance report.","author":"The Environmental Institute of Science and Research Limited","year":"2011","unstructured":"The Environmental Institute of Science and Research Limited. 2011. Sexually transmitted infections in New Zealand: annual surveillance report. The Environmental Institute of Science and Research Limited, Wellington, New Zealand."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1071\/SH10134"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01581-08"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02398-09"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2010.042812"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01217-11"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2012-050535"},{"key":"e_1_3_2_12_2","volume-title":"Roche cobas\u00ae 4800 CT\/NG test: package insert, V4.0.","author":"Roche Molecular Systems","year":"2011","unstructured":"Roche Molecular Systems. 2011. Roche cobas\u00ae 4800 CT\/NG test: package insert, V4.0. 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Intell. 29:358\u2013365.","journal-title":"Commun. Dis. Intell."},{"key":"e_1_3_2_18_2","unstructured":"Clinical Effectiveness Group British Association for Sexual Health and HIV. 2011. UK national guideline for the management of gonorrhoea in adults 2011. http:\/\/www.bashh.org\/guidelines."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05341-11"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70603-8"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000190092.59482.96"},{"key":"e_1_3_2_22_2","first-page":"579","article-title":"Neisseria gonorrhoeae with reduced susceptibility to azithromycin","volume":"60","author":"Centres for Disease Control and Prevention","year":"2011","unstructured":"Centres for Disease Control and Prevention. 2011. Neisseria gonorrhoeae with reduced susceptibility to azithromycin. MMWR 60:579\u2013581.","journal-title":"MMWR"},{"key":"e_1_3_2_23_2","first-page":"873","article-title":"Cephalosporin susceptibility among Neisseria gonorrhoeae isolates","volume":"60","author":"Centres for Disease Control and Prevention","year":"2011","unstructured":"Centres for Disease Control and Prevention. 2011. Cephalosporin susceptibility among Neisseria gonorrhoeae isolates. MMWR 60:873\u2013877.","journal-title":"MMWR"},{"key":"e_1_3_2_24_2","first-page":"1","article-title":"HIV prevention through early detection and treatment of other sexually transmitted diseases\u2014United States Recommendations of the Advisory Committee for HIV and STD Prevention","volume":"47","author":"Centres for Disease Control and Prevention","year":"1998","unstructured":"Centres for Disease Control and Prevention. 1998. HIV prevention through early detection and treatment of other sexually transmitted diseases\u2014United States Recommendations of the Advisory Committee for HIV and STD Prevention. 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