{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:48:00Z","timestamp":1792723680639,"version":"4.5.0"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Plasmodium knowlesi<\/jats:named-content>\n            can cause severe and fatal human malaria in Southeast Asia. Rapid diagnosis of all\n            <jats:named-content content-type=\"genus-species\">Plasmodium<\/jats:named-content>\n            species is essential for initiation of effective treatment. Rapid diagnostic tests (RDTs) are sensitive for detection of uncomplicated and severe falciparum malaria but have not been systematically evaluated in knowlesi malaria. At a tertiary referral hospital in Sabah, Malaysia, we prospectively evaluated the sensitivity of two combination RDTs for the diagnosis of uncomplicated and severe malaria from all three potentially fatal\n            <jats:named-content content-type=\"genus-species\">Plasmodium<\/jats:named-content>\n            species, using a pan-\n            <jats:named-content content-type=\"genus-species\">Plasmodium<\/jats:named-content>\n            lactate dehydrogenase (pLDH)-\n            <jats:named-content content-type=\"genus-species\">P. falciparum<\/jats:named-content>\n            histidine-rich protein 2 (PfHRP2) RDT (First Response) and a pan-\n            <jats:named-content content-type=\"genus-species\">Plasmodium<\/jats:named-content>\n            aldolase-PfHRP2 RDT (ParaHIT). Among 293 hospitalized adults with PCR-confirmed\n            <jats:named-content content-type=\"genus-species\">Plasmodium<\/jats:named-content>\n            monoinfection, the sensitivity of the pLDH component of the pLDH-PfHRP2 RDT was 74% (95\/129; 95% confidence interval [CI], 65 to 80%), 91% (110\/121; 95% CI, 84 to 95%), and 95% (41\/43; 95% CI, 85 to 99%) for PCR-confirmed\n            <jats:named-content content-type=\"genus-species\">P. knowlesi<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">P. falciparum<\/jats:named-content>\n            , and\n            <jats:named-content content-type=\"genus-species\">P. vivax<\/jats:named-content>\n            infections, respectively, and 88% (30\/34; 95% CI, 73 to 95%), 90% (38\/42; 95% CI, 78 to 96%), and 100% (12\/12; 95% CI, 76 to 100%) among patients tested before antimalarial treatment was begun. Sensitivity in severe malaria was 95% (36\/38; 95% CI, 83 to 99), 100% (13\/13; 95% CI, 77 to 100), and 100% (7\/7; 95% CI, 65 to 100%), respectively. The aldolase component of the aldolase-PfHRP2 RDT performed poorly in all\n            <jats:named-content content-type=\"genus-species\">Plasmodium<\/jats:named-content>\n            species. The pLDH-based RDT was highly sensitive for the diagnosis of severe malaria from all species; however, neither the pLDH- nor aldolase-based RDT demonstrated sufficiently high overall sensitivity for\n            <jats:named-content content-type=\"genus-species\">P. knowlesi<\/jats:named-content>\n            . More sensitive RDTs are needed in regions of\n            <jats:named-content content-type=\"genus-species\">P. knowlesi<\/jats:named-content>\n            endemicity.\n          <\/jats:p>","DOI":"10.1128\/jcm.03285-12","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T09:51:49Z","timestamp":1359021109000},"page":"1118-1123","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":85,"title":["Evaluation of the Sensitivity of a pLDH-Based and an Aldolase-Based Rapid Diagnostic Test for Diagnosis of Uncomplicated and Severe Malaria Caused by PCR-Confirmed Plasmodium knowlesi, Plasmodium falciparum, and Plasmodium vivax"],"prefix":"10.1128","volume":"51","author":[{"given":"Bridget E.","family":"Barber","sequence":"first","affiliation":[{"name":"Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia"},{"name":"Infectious Diseases Unit, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"William","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia"},{"name":"Sabah Department of Health, Kota Kinabalu, Sabah, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Grigg","sequence":"additional","affiliation":[{"name":"Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia"},{"name":"Infectious Diseases Unit, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Piera","sequence":"additional","affiliation":[{"name":"Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsin W.","family":"Yeo","sequence":"additional","affiliation":[{"name":"Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia"},{"name":"Royal Darwin Hospital, Darwin, Northern Territory, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Anstey","sequence":"additional","affiliation":[{"name":"Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia"},{"name":"Royal Darwin Hospital, Darwin, Northern Territory, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-401"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/605439"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/104284"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/524888"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1705.101489"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002026"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir180"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3283558780"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1707.101017"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-284"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis902"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00035-07"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-129"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-262"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.1.203-206.1998"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2011.10-0622"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-9-219"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1509.090358"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2009.80.927"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2009.06.004"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir143"},{"key":"e_1_3_3_23_2","first-page":"186","article-title":"Comparison of different diagnostic techniques in Plasmodium falciparum cerebral malaria","volume":"43","author":"Shujatullah F","year":"2006","unstructured":"ShujatullahF MalikA KhanHM . 2006. Comparison of different diagnostic techniques in Plasmodium falciparum cerebral malaria. J. Vector Borne Dis. 43:186\u2013190.","journal-title":"J. Vector Borne Dis"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32832f14c1"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048701"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32832f14c1"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2009.02.003"},{"key":"e_1_3_3_28_2","unstructured":"World Health Organization. 2010. Malaria rapid diagnostic test performance. Summary results of WHO product testing of malaria RDTs: rounds 1 and 2 (2008\u20132009). WHO Geneva Switzerland. http:\/\/www2.wpro.who.int\/NR\/rdonlyres\/E4823BBF-69FC-45DE-B924-1A9FCDD7406C\/0\/RoundIII_SummaryFINAL.pdf."},{"key":"e_1_3_3_29_2","volume-title":"Management of severe malaria: a practical handbook","author":"World Health Organization","year":"2012","unstructured":"World Health Organization. 2012. Management of severe malaria: a practical handbook, 3rd ed. World Health Organization, Geneva, Switzerland.","edition":"3"},{"key":"e_1_3_3_30_2","unstructured":"World Health Organization. 2010. Guidelines for the treatment of malaria 2nd ed. World Health Organization Geneva Switzerland. http:\/\/www.who.int\/malaria\/publications\/atoz\/9789241547925\/en\/index.html."},{"key":"e_1_3_3_31_2","unstructured":"WHO. 2012. Information note on recommended selection criteria for procurement of malaria rapid diagnostic tests (RDTs). WHO Global Malaria Programme Geneva Switzerland. http:\/\/www.who.int\/malaria\/diagnosis_treatment\/diagnosis\/RDT_selection_criteria.pdf."},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1179\/000349803125002977"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00811-09"},{"key":"e_1_3_3_34_2","first-page":"48","article-title":"Case report: fatal Plasmodium knowlesi malaria following an atypical clinical presentation and delayed diagnosis","volume":"68","author":"Rajahram GS","year":"2013","unstructured":"RajahramGS BarberBE TanWM YeoTW WilliamT . 2013. Case report: fatal Plasmodium knowlesi malaria following an atypical clinical presentation and delayed diagnosis. Med. J. Malaysia 68:48\u201349.","journal-title":"Med. J. Malaysia"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043094"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008091"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1086\/432010"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02557-05"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-9-191"},{"key":"e_1_3_3_40_2","unstructured":"World Health Organization. 2011. Malaria rapid diagnostic test performance. Results of WHO product testing of malaria RDTs: round 3 (2010\u20132011). World Health Organization Geneva Switzerland. http:\/\/www.who.int\/tdr\/publications\/documents\/rdt3.pdf."},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.8.2412-2417.1999"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-8"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1411.080840"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1524"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.03285-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.03285-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T20:40:23Z","timestamp":1646426423000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.03285-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1128\/JCM.03285-12"],"URL":"https:\/\/doi.org\/10.1128\/jcm.03285-12","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"2012-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}