{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:17:15Z","timestamp":1784603835599,"version":"3.55.0"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Lyme disease prevails as the most commonly transmitted tick-borne infection in the United States, and serologic evaluation for antibodies to\n            <jats:named-content content-type=\"genus-species\">Borrelia burgdorferi<\/jats:named-content>\n            remains the recommended modality for diagnosis. This review presents a brief historical perspective on the evolution of serologic assays for Lyme disease and provides a summary of the performance characteristics for the currently recommended two-tiered testing algorithm (TTTA). Additionally, a recently proposed alternative to the traditional TTTA is discussed, and novel methodologies, including immuno-PCR and metabolic profiling for Lyme disease, are outlined.\n          <\/jats:p>","DOI":"10.1128\/jcm.03394-15","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T20:33:22Z","timestamp":1455222802000},"page":"1191-1196","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":65,"title":["The Past, Present, and (Possible) Future of Serologic Testing for Lyme Disease"],"prefix":"10.1128","volume":"54","author":[{"given":"Elitza S.","family":"Theel","sequence":"first","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu397"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2109.150417"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.3.484-509.2005"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2015.07.005"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1314325"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.1.1-9.1996"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/589242"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03490070073045"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.2.392"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.2.419-427.1995"},{"key":"e_1_3_1_12_2","first-page":"590","article-title":"Recommendations for test performance and interpretation from the Second National Conference of Serologic Diagnosis of Lyme","volume":"44","author":"Centers for Disease Control and Prevention","year":"1995","unstructured":"Centers for Disease Control and Prevention. 1995. Recommendations for test performance and interpretation from the Second National Conference of Serologic Diagnosis of Lyme. MMWR Morb Mortal Wkly Rep 44:590\u2013591.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.121"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2015.07.002"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.09.003"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2011.06.005"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00195-08"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir464"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu703"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.7.1733-1738.1994"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1086\/374395"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00608-12"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.11.4662-4672.1992"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03749.x"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00200-08"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01853-13"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02111-15"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00630-12"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2005.02.006"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ185"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.03394-15","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.03394-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T08:43:29Z","timestamp":1646469809000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.03394-15"}},"subtitle":[],"editor":[{"given":"C. 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