{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:02:58Z","timestamp":1791846178513,"version":"4.3.4"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Tests for\n            <jats:named-content content-type=\"genus-species\">Chlamydia trachomatis<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Neisseria gonorrhoeae<\/jats:named-content>\n            , which can provide results rapidly to guide therapeutic decision-making, offer patient care advantages over laboratory-based tests that require several days to provide results. We compared results from the Cepheid GeneXpert CT\/NG (Xpert) assay to results from two currently approved nucleic acid amplification assays in 1,722 female and 1,387 male volunteers. Results for chlamydia in females demonstrated sensitivities for endocervical, vaginal, and urine samples of 97.4%, 98.7%, and 97.6%, respectively, and for urine samples from males, a sensitivity of 97.5%, with all specificity estimates being \u226599.4%. Results for gonorrhea in females demonstrated sensitivities for endocervical, vaginal, and urine samples of 100.0%, 100.0%, and 95.6%, respectively, and for urine samples from males, a sensitivity of 98.0%, with all estimates of specificity being \u226599.8%. These results indicate that this short-turnaround-time test can be used to accurately test patients and to possibly do so at the site of care, thus potentially improving chlamydia and gonorrhea control efforts.\n          <\/jats:p>","DOI":"10.1128\/jcm.03461-12","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T21:51:57Z","timestamp":1362606717000},"page":"1666-1672","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":253,"title":["Performance of the Cepheid CT\/NG Xpert Rapid PCR Test for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae"],"prefix":"10.1128","volume":"51","author":[{"given":"Charlotte A.","family":"Gaydos","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Johns Hopkins Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Van Der Pol","sequence":"additional","affiliation":[{"name":"Indiana University School of Public Health, Department of Epidemiology &amp; Biostatistics, Bloomington, Indiana, USA"},{"name":"Indiana University School of Medicine, Division of Infectious Diseases, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Jett-Goheen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Johns Hopkins Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilda","family":"Barnes","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Johns Hopkins Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Quinn","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Johns Hopkins Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carey","family":"Clark","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham and Jefferson County Health Department, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace E.","family":"Daniel","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine, Division of Infectious Diseases, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula B.","family":"Dixon","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham and Jefferson County Health Department, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Edward W.","family":"Hook","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham and Jefferson County Health Department, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The CT\/NG Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"U.S. Department of Health and Human Services. 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