{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:25:05Z","timestamp":1760646305259},"reference-count":58,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In this study, we introduce a new approach for determination of epidemiologic cutoffs (ECOFFs) and resistant-population cutoffs (RCOFFs) based on receiver operating characteristic (ROC) curves. As an example, the method was applied for determination of ECOFFs for seven different beta-lactam antibiotics and wild-type populations of\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">Klebsiella pneumoniae<\/jats:named-content>\n            , and\n            <jats:named-content content-type=\"genus-species\">Enterobacter cloacae<\/jats:named-content>\n            . In addition, RCOFFs were determined for bacterial populations with defined resistance mechanisms (\u201cresistotypes\u201d), i.e., extended-spectrum beta-lactamase (ESBL)-positive\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            , ESBL-positive\n            <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n            , and ESBL-positive\n            <jats:named-content content-type=\"genus-species\">E. cloacae<\/jats:named-content>\n            ; AmpC cephalosporinase-positive\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            and AmpC-positive\n            <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n            ; and broad-spectrum beta-lactamase (BSBL)-positive\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            . RCOFFs and ECOFFs are instrumental for a systematic characterization of associations between resistotypes and wild-type populations.\n          <\/jats:p>","DOI":"10.1128\/jcm.03506-14","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T02:22:55Z","timestamp":1426126975000},"page":"1812-1822","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["A Statistical Approach for Determination of Disk Diffusion-Based Cutoff Values for Systematic Characterization of Wild-Type and Non-Wild-Type Bacterial Populations in Antimicrobial Susceptibility Testing"],"prefix":"10.1128","volume":"53","author":[{"given":"Giorgia","family":"Valsesia","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Roos","sequence":"additional","affiliation":[{"name":"Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik C.","family":"B\u00f6ttger","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hombach","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"Zone diameter distributions","author":"European Committee on Antimicrobial Susceptibility Testing","year":"2014","unstructured":"European Committee on Antimicrobial Susceptibility Testing. 2014. 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