{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:20:17Z","timestamp":1765887617361},"reference-count":18,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n In a comparison of 4 second-generation nucleic acid amplification tests performed with self-collected vaginal swab (SCVS) and first-void urine (FVU) specimens from 575 women, SCVS specimens indicated more infections than did FVU specimens in all assays. The prevalence rates were 9% (53\/575 patients) for\n Chlamydia trachomatis<\/jats:named-content>\n and 2% (11\/575 patients) for\n Neisseria gonorrhoeae<\/jats:named-content>\n . The clinical sensitivities for testing SCVS specimens for\n C. trachomatis<\/jats:named-content>\n were 98.1% on a Tigris system and 96.2% on a Panther system for the Aptima Combo 2 assay (Hologic Gen-Probe), 98.0% for the RealTi\n m<\/jats:italic>\n e CT\/NG assay on an m2000 instrument (Abbott), 90.6% for the ProbeTec CT\/GC Q\n \n x<\/jats:italic>\n <\/jats:sup>\n assay on the Viper system (Becton Dickinson), and 84.6% for the cobas CT\/NG assay on the cobas 4800 platform (Roche). Clinical sensitivities for\n C. trachomatis<\/jats:named-content>\n in FVU specimens were 88.7% (Tigris) and 88.0% (Panther) for the Aptima Combo 2 assay, 76.9% for the RealTi\n m<\/jats:italic>\n e CT\/NG assay, 75.5% for the ProbeTec CT\/GC Q\n \n x<\/jats:italic>\n <\/jats:sup>\n assay, and 81.1% for the cobas CT\/NG assay. Clinical sensitivities of the assays for\n N. gonorrhoeae<\/jats:named-content>\n , with limited positive results, ranged from 63.6% to 100%. Specificities for both infections ranged from 98.4 to 100%. Differences in analytical sensitivities and levels of molecular targets in clinical samples but not inhibitors of amplification may explain the differences in clinical sensitivities.\n <\/jats:p>","DOI":"10.1128\/jcm.03552-13","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T06:17:43Z","timestamp":1396505863000},"page":"2305-2310","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Head-to-Head Comparison of Second-Generation Nucleic Acid Amplification Tests for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae on Urine Samples from Female Subjects and Self-Collected Vaginal Swabs"],"prefix":"10.1128","volume":"52","author":[{"given":"Max","family":"Chernesky","sequence":"first","affiliation":[{"name":"St. Joseph's Healthcare\/McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Jang","sequence":"additional","affiliation":[{"name":"St. Joseph's Healthcare\/McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodi","family":"Gilchrist","sequence":"additional","affiliation":[{"name":"St. Joseph's Healthcare\/McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd","family":"Hatchette","sequence":"additional","affiliation":[{"name":"Queen Elizabeth II Health Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Poirier","sequence":"additional","affiliation":[{"name":"Centre de sant\u00e9 et de services sociaux de Trois-Rivi\u00e8res, Trois-Rivi\u00e8res, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Frederic","family":"Flandin","sequence":"additional","affiliation":[{"name":"Public Health Laboratory, St. John's, Newfoundland and Labrador, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Smieja","sequence":"additional","affiliation":[{"name":"St. Joseph's Healthcare\/McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Ratnam","sequence":"additional","affiliation":[{"name":"Division of Community Health and Humanities, Memorial University, St. John's, Newfoundland and Labrador, Canada"},{"name":"Department of Oncology, McGill University, Montreal, Quebec, 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