{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:31:18Z","timestamp":1792020678415,"version":"4.4.0"},"reference-count":62,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Serum 1,3-\u03b2-\n            <jats:sc>d<\/jats:sc>\n            -glucan (BG) assay may be helpful as a marker for the diagnosis of\n            <jats:named-content content-type=\"genus-species\">Pneumocystis jiroveci<\/jats:named-content>\n            pneumonia (PJP) and invasive fungal infection (IFI). We conducted a systematic review to assess the diagnostic accuracy of this assay. We searched MEDLINE, Web of Science, Cochrane Collaboration databases, Ichushi-Web, reference lists of retrieved studies, and review articles. Our search included studies of serum BG assay that used (i) positive cytological or direct microscopic examination of sputum or bronchoalveolar lavage fluid for PJP and (ii) European Organization for Research and Treatment of Cancer or similar criteria for IFI as a reference standard and provided data to calculate sensitivity and specificity. Only major fungal infections such as invasive candidiasis and invasive aspergillosis were included in the IFI group. Twelve studies for PJP and 31 studies for IFI were included from January 1966 to November 2010. The pooled sensitivity, specificity, diagnostic odds ratio (DOR), and area under the summary receiver operating characteristic curve (AUC-SROC) for PJP were 96% (95% confidence interval [95% CI], 92% to 98%), 84% (95% CI, 83% to 86%), 102.3 (95% CI, 59.2 to 176.6) and 0.96 (95% CI, 0.94 to 0.99), respectively. No heterogeneity was found. For IFI, the values were 80% (95% CI, 77% to 82%), 82% (95% CI, 81% to 83%), 25.7 (95% CI, 15.0 to 44.1), and 0.88 (95% CI, 0.82 to 0.93). Heterogeneity was significant. The diagnostic accuracy of the BG assay is high for PJP and moderate for IFI. Because the sensitivity for PJP is particularly high, the BG assay can be used as a screening tool for PJP.\n          <\/jats:p>","DOI":"10.1128\/jcm.05267-11","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T02:59:33Z","timestamp":1320980373000},"page":"7-15","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":303,"title":["Diagnostic Accuracy of Serum 1,3-\u03b2-\n            <scp>d<\/scp>\n            -Glucan for Pneumocystis jiroveci Pneumonia, Invasive Candidiasis, and Invasive Aspergillosis: Systematic Review and Meta-Analysis"],"prefix":"10.1128","volume":"50","author":[{"given":"Akira","family":"Onishi","sequence":"first","affiliation":[{"name":"Departments of Evidence Based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Departments of Evidence Based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Kogata","sequence":"additional","affiliation":[{"name":"Departments of Evidence Based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Saegusa","sequence":"additional","affiliation":[{"name":"Departments of Evidence Based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Kawano","sequence":"additional","affiliation":[{"name":"Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Morinobu","sequence":"additional","affiliation":[{"name":"Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Departments of Evidence Based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan"},{"name":"Division of Evidence-Based Medicine and Risk Analysis, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Departments of Evidence Based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan"},{"name":"Department of Rheumatic Diseases, Shinko Hospital, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1469-0691.2010.03357.x","article-title":"A prospective comparison of galactomannan in bronchoalveolar lavage fluid for the diagnosis of pulmonary invasive aspergillosis in medical patients under intensive care: comparison with the diagnostic performance of galactomannan and of (1\u21923)-beta-d-glucan chromogenic assay in serum samples","volume":"17","author":"Acosta J","year":"2011","unstructured":"AcostaJ. 2011. A prospective comparison of galactomannan in bronchoalveolar lavage fluid for the diagnosis of pulmonary invasive aspergillosis in medical patients under intensive care: comparison with the diagnostic performance of galactomannan and of (1\u21923)-beta-d-glucan chromogenic assay in serum samples. Clin. Microbiol. Infect. 17:1053\u20131060.","journal-title":"Clin. Microbiol. 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Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC\/MSG) consensus group. Clin. Infect. Dis. 46:1813\u20131821.","journal-title":"Clin. Infect. 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Detection of 1,3-beta-d glucan for diagnosis of invasive fungal infections in hematooncological patients: usefulness for screening of invasive mycosis and for confirmation of galactomannan positive results. Klin. Mikrobiol. Infekc. Lek. 15:48\u201357.","journal-title":"Klin. Mikrobiol. Infekc. Lek."},{"key":"e_1_3_2_53_2","unstructured":"ReitsmaJB. 2009. Chapter 9: assessing methodological quality. In DeeksJJ\nBossuytPM\nGatsonisC (ed). Cochrane handbook for systematic reviews of diagnostic test accuracy version 1.0.0. The Cochrane Collaboration. http:\/\/srdta.cochrane.org\/."},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.050090"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1086\/527382"},{"key":"e_1_3_2_56_2","volume-title":"Methods for meta-analysis in medical research","author":"Sutton A","year":"2000","unstructured":"SuttonA JonesD SheldonT SongF. 2000. Methods for meta-analysis in medical research. 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Zhongguo Dang Dai Er Ke Za Zhi 11:905\u2013908.","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.05267-11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.05267-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T11:03:48Z","timestamp":1646478228000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.05267-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1128\/JCM.05267-11"],"URL":"https:\/\/doi.org\/10.1128\/jcm.05267-11","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"2011-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-10-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-12-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}