{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:32:11Z","timestamp":1787067131777,"version":"build-2736575974"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n A new species of nonsporulating fungus, isolated in a case of black-grain mycetoma in Sudan, is described as\n Madurella fahalii<\/jats:named-content>\n . The species is characterized by phenotypic and molecular criteria. Multigene phylogenies based on the ribosomal DNA (rDNA) internal transcribed spacer (ITS), the partial \u03b2-tubulin gene (\n BT2<\/jats:italic>\n ), and the RNA polymerase II subunit 2 gene (\n RPB2<\/jats:italic>\n ) indicate that\n M. fahalii<\/jats:named-content>\n is closely related to\n Madurella mycetomatis<\/jats:named-content>\n and\n M. pseudomycetomatis<\/jats:named-content>\n ; the latter name is validated according to the rules of botanical nomenclature.\n Madurella ikedae<\/jats:named-content>\n was found to be synonymous with\n M. mycetomatis<\/jats:named-content>\n . An isolate from Indonesia was found to be different from all known species based on multilocus analysis and is described as\n Madurella tropicana. Madurella<\/jats:named-content>\n is nested within the order Sordariales, with\n Chaetomium<\/jats:named-content>\n as its nearest neighbor.\n Madurella fahalii<\/jats:named-content>\n has a relatively low optimum growth temperature (30\u00b0C) and is less susceptible to the azoles than other\n Madurella<\/jats:named-content>\n species, with voriconazole and posaconazole MICs of 1 \u03bcg\/ml, a ketoconazole MIC of 2 \u03bcg\/ml, and an itraconazole MIC of >16 \u03bcg\/ml. Since eumycetoma is still treated only with azoles, correct species identification is important for the optimal choice of antifungal therapy.\n <\/jats:p>","DOI":"10.1128\/jcm.05477-11","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T21:57:26Z","timestamp":1325109446000},"page":"988-994","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":72,"title":["New Species of Madurella, Causative Agents of Black-Grain Mycetoma"],"prefix":"10.1128","volume":"50","author":[{"given":"G. Sybren","family":"de Hoog","sequence":"first","affiliation":[{"name":"Centraalbureau voor Schimmelcultures KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands"},{"name":"Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Peking University Health Science Center, Research Center for Medical Mycology, Beijing, China"},{"name":"Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne D.","family":"van Diepeningen","sequence":"additional","affiliation":[{"name":"Centraalbureau voor Schimmelcultures KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El-Sheikh","family":"Mahgoub","sequence":"additional","affiliation":[{"name":"Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy W. J.","family":"van de Sande","sequence":"additional","affiliation":[{"name":"Erasmus Medical Center, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32803d38fe"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.12.5813-5816.2003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.7.2742-2746.2004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(04)01131-4"},{"key":"e_1_3_2_6_2","first-page":"741","article-title":"Nouveau cas de Myc\u00e9tome \u00e0 grains noirs observ\u00e9 en Tunisie","volume":"12","author":"Blanc G","year":"1919","unstructured":"BlancG BrunG. 1919. Nouveau cas de Myc\u00e9tome \u00e0 grains noirs observ\u00e9 en Tunisie. Bull. Soc. Pathol. Exot. 12:741\u2013748.","journal-title":"Bull. Soc. 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