{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:18:57Z","timestamp":1783606737696,"version":"3.55.0"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            This study investigated \u201ccreep\u201d in vancomycin and daptomycin MICs among methicillin-resistant\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            (MRSA) isolates from blood cultures over a 5-year period in a hospital in the United Kingdom, using different susceptibility testing methods. Trends in vancomycin and daptomycin susceptibility were evaluated by using Etest performed prospectively on isolates in routine clinical practice from December 2007 to December 2010 (\n            <jats:italic>n<\/jats:italic>\n            = 102). Comparison was made to results from prospective testing of subcultures at the Scottish MRSA Reference Laboratory, using an automated system (Vitek 2) and retrospective testing (Etest and CLSI reference broth microdilution [BMD] method) of stored isolates from 2006 to 2010 (\n            <jats:italic>n<\/jats:italic>\n            = 208). Spearman's rank correlations revealed a significant increase in vancomycin MIC (\n            <jats:italic>P<\/jats:italic>\n            = 0.012) and a significant decrease in daptomycin MIC (\n            <jats:italic>P<\/jats:italic>\n            = 0.03) by year of study for Etest results from the time of isolation. However, neither trend was replicated in MICs from automated or retrospective testing. The Friedman test revealed a significant difference between vancomycin MICs obtained from the same samples by different testing methods (\u03c7\n            <jats:sup>2<\/jats:sup>\n            [3 degrees of freedom] = 97;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). MICs from automated testing and Etest analysis of stored isolates were significantly lower than those from Etest analysis at the time of isolation for both antibiotics (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). Effects of storage on the MIC appeared within the first 6 months of storage. Inconsistent evidence on vancomycin MIC creep and the relevance of the MIC to clinical outcome may arise from differences in susceptibility testing methods, including storage of isolates. There is a need to standardize and streamline susceptibility testing of vancomycin against MRSA.\n          <\/jats:p>","DOI":"10.1128\/jcm.05520-11","type":"journal-article","created":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T13:55:54Z","timestamp":1322834154000},"page":"318-325","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["Is Vancomycin MIC \u201cCreep\u201d Method Dependent? Analysis of Methicillin-Resistant Staphylococcus aureus Susceptibility Trends in Blood Isolates from North East Scotland from 2006 to 2010"],"prefix":"10.1128","volume":"50","author":[{"given":"B.","family":"Edwards","sequence":"first","affiliation":[{"name":"Medical Microbiology Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Milne","sequence":"additional","affiliation":[{"name":"Medical Microbiology Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Lawes","sequence":"additional","affiliation":[{"name":"Infection Unit, Aberdeen Royal Infirmary, Aberdeen, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Cook","sequence":"additional","affiliation":[{"name":"Medical Microbiology Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Robb","sequence":"additional","affiliation":[{"name":"Scottish MRSA Reference Laboratory, Stobhill Hospital, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. M.","family":"Gould","sequence":"additional","affiliation":[{"name":"Medical Microbiology Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn246"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.6.887"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-28-2-151"},{"key":"e_1_3_2_5_2","volume-title":"Abstr. 21st Eur. Cong. Clin. Microbiol. Infect. Dis.","author":"Edwards B","year":"2011","unstructured":"EdwardsB MilneK LawesT CookI GouldIM. 2011. Vancomycin susceptibility trends in MRSA isolated from blood cultures in Aberdeen Royal Infirmary from 2006\u20132010. Is vancomycin \u201ccreep\u201d method dependent?, abstr. P765. Abstr. 21st Eur. Cong. Clin. Microbiol. Infect. 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