{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:07:10Z","timestamp":1790791630199,"version":"4.1.0"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Leptotrichia<\/jats:named-content>\n            spp. are anaerobic, pencil-shaped, Gram-negative rods that are part of the normal oral and intestinal human flora. Although not typically considered pathogenic, invasive\n            <jats:named-content content-type=\"genus-species\">Leptotrichia<\/jats:named-content>\n            infections have been reported in immunosuppressed patients. A perceived rise in the identification of\n            <jats:named-content content-type=\"genus-species\">Leptotrichia<\/jats:named-content>\n            spp. at our institution prompted a retrospective evaluation of these infections. Laboratory and clinical records were reviewed to identify\n            <jats:named-content content-type=\"genus-species\">Leptotrichia<\/jats:named-content>\n            culture-positive patients. Over a 5-year period, 68\n            <jats:named-content content-type=\"genus-species\">Leptotrichia<\/jats:named-content>\n            -positive specimens were identified. Of these, 21% (14\/68) were identified in original samples submitted from 13 different patients at our institution, and the remainder (79% [54\/68]) were unknown isolates referred from outside hospitals for molecular identification. All in-house\n            <jats:named-content content-type=\"genus-species\">Leptotrichia<\/jats:named-content>\n            were identified from blood cultures. Only 64% (9\/14) of these grew on solid media, and 5 were a part of polymicrobial bacteremias containing other enteric pathogens. All local patients were receiving chemotherapy and a majority received hematopoietic stem cell transplant (HSCT) (11\/13). All had neutropenic fever with symptoms of mucositis and\/or enteritis. Most of the HSCT patients (73% [8\/11]) were autologous recipients hospitalized after recent high-dose chemotherapy for multiple myeloma.\n            <jats:named-content content-type=\"genus-species\">L. hongkongensis<\/jats:named-content>\n            , a novel species, was found in the majority of myeloma cases (63% [5\/8]). In conclusion, we suggest that\n            <jats:named-content content-type=\"genus-species\">Leptotrichia<\/jats:named-content>\n            spp. may be an underappreciated cause of bacteremia, particularly in multiple myeloma patients receiving cytotoxic chemotherapy for autologous HSCT. In our cohort, these infections were associated with neutropenic fever from an enteric source, and most isolates remained sensitive to standard antibiotics.\n          <\/jats:p>","DOI":"10.1128\/jcm.05926-11","type":"journal-article","created":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T02:57:26Z","timestamp":1325127446000},"page":"1228-1232","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":63,"title":["Leptotrichia Bacteremia in Patients Receiving High-Dose Chemotherapy"],"prefix":"10.1128","volume":"50","author":[{"given":"Marc Roger","family":"Couturier","sequence":"first","affiliation":[{"name":"Associated Regional and University Pathologists, Inc., Salt Lake City, Utah, USA"},{"name":"Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Susan","family":"Slechta","sequence":"additional","affiliation":[{"name":"ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Goulston","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Associated Regional and University Pathologists, Inc., Salt Lake City, Utah, USA"},{"name":"Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly E.","family":"Hanson","sequence":"additional","affiliation":[{"name":"Associated Regional and University Pathologists, Inc., Salt Lake City, Utah, USA"},{"name":"Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA"},{"name":"Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01407.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0406-1"},{"key":"e_1_3_2_4_2","unstructured":"CLSI. 2008. 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Koneman's color atlas and textbook of diagnostic microbiology 6th ed. Lippincott\/The Williams & Wilkins Co. Philadelphia PA."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1000056"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.05926-11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.05926-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T11:12:41Z","timestamp":1646478761000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.05926-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1128\/JCM.05926-11"],"URL":"https:\/\/doi.org\/10.1128\/jcm.05926-11","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"2011-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-12-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}