{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:01:19Z","timestamp":1768813279522,"version":"3.49.0"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The next-generation amplification test for\n            <jats:named-content content-type=\"genus-species\">Chlamydia trachomatis<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Neisseria gonorrhoeae<\/jats:named-content>\n            (Roche cobas 4800), a fully automated system, was compared head to head, using female samples, to Gen-Probe Aptima Combo 2 and BD ProbeTec using Viper. Endocervical swabs, female urine, and endocervical samples in liquid-based cytology medium were run on at least two of three platforms. A total of 4,316 samples were evaluated, and 281 chlamydial and 69 gonococcal infections were identified. Estimates of sensitivity and specificity were obtained relative to the patient infection standard (PIS) and using latent class analysis (LCA). Chlamydia sensitivity estimates ranged from 86.9 to 95.6% using PIS and 97.6 to 98% using LCA. Specificity was \u226599.6% for all sample types. Sensitivity ranged from 95.6 to 100% using PIS and 96.9 to 100% using LCA for the detection of gonococcal infections. Specificity for gonococcal infections was \u226599.8%. cobas 4800 performance was equivalent to the comparator assays (all\n            <jats:italic>P<\/jats:italic>\n            values, &gt;0.05), and the fully automated system provides high laboratory efficiency.\n          <\/jats:p>","DOI":"10.1128\/jcm.06481-11","type":"journal-article","created":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T00:13:41Z","timestamp":1334880821000},"page":"2244-2249","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":67,"title":["Performance of the cobas CT\/NG Test Compared to the Aptima AC2 and Viper CTQ\/GCQ Assays for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae"],"prefix":"10.1128","volume":"50","author":[{"given":"Barbara","family":"Van Der Pol","sequence":"first","affiliation":[{"name":"Indiana University School of Public Health, Department of Epidemiology &amp; Biostatistics, Bloomington, Indiana, USA"},{"name":"Indiana University School of Medicine, Division of Infectious Diseases, Indianapolis, Indiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Liesenfeld","sequence":"additional","affiliation":[{"name":"Roche Molecular Systems, Pleasanton, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine, Division of Infectious Diseases, Indianapolis, Indiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie N.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca A.","family":"Lillis","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"Body","sequence":"additional","affiliation":[{"name":"Laboratory Corporation of America, Burlington, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mindy","family":"Nye","sequence":"additional","affiliation":[{"name":"Laboratory Corporation of America, Burlington, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Eisenhut","sequence":"additional","affiliation":[{"name":"DCL Laboratories (Laboratory Corporation of America), Indianapolis, Indiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Edward W.","family":"Hook","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham and Jefferson County Health Department, Birmingham, Alabama, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00223-07"},{"key":"e_1_3_2_3_2","first-page":"E070614.4","article-title":"Prevalence of the new genetic variant of Chlamydia trachomatis in Sodra Alvsborg County, Vastra Gotaland Region, Sweden","volume":"12","author":"Bjorkman J","year":"2007","unstructured":"BjorkmanJ JonssonL NilssonP. 2007. 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