{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:50:09Z","timestamp":1787928609494,"version":"build-2784847793"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Multiplex, real-time PCR for the identification of\n            <jats:named-content content-type=\"genus-species\">Ureaplasma urealyticum<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Ureaplasma parvum<\/jats:named-content>\n            was performed on nucleic acids extracted from sequential endotracheal aspirates obtained from preterm neonates born at &lt;29 weeks of gestation and ventilated for more than 48 h admitted to two level 3 neonatal intensive care units. Specimens were obtained shortly after birth and sequentially up until extubation. One hundred fifty-two specimens (93.8%) contained material suitable for analysis.\n            <jats:named-content content-type=\"genus-species\">Ureaplasma<\/jats:named-content>\n            spp. were identified in 5 of 13 neonates studied. In most cases, the DNA load of the detected\n            <jats:named-content content-type=\"genus-species\">Ureaplasma<\/jats:named-content>\n            species was low and decreased over time. In addition, changes in detectable\n            <jats:named-content content-type=\"genus-species\">Ureaplasma<\/jats:named-content>\n            species DNA did not relate to changes in the inflammatory marker C-reactive protein (CRP) or respiratory status. All but two blood samples obtained at times of suspected sepsis were culture positive for other microorganisms; the species cultured were typically coagulase-negative staphylococci and were associated with increased levels of CRP (&gt;10 mg\/liter). This study was limited by the small number of patients examined and does not have the power to support or contradict the hypothesis that postnatal lung infection with\n            <jats:named-content content-type=\"genus-species\">Ureaplasma parvum<\/jats:named-content>\n            is causally related to bronchopulmonary dysplasia (BPD) or adverse respiratory outcomes after preterm birth. However, in this study, increases in CRP levels were not associated with patients in whom\n            <jats:named-content content-type=\"genus-species\">Ureaplasma parvum<\/jats:named-content>\n            was detected, in contrast to the detection of other bacterial species.\n          <\/jats:p>","DOI":"10.1128\/jcm.06625-11","type":"journal-article","created":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T02:24:53Z","timestamp":1324520693000},"page":"909-914","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["A Quantitative Analysis of Ureaplasma urealyticum and Ureaplasma parvum Compared with Host Immune Response in Preterm Neonates at Risk of Developing Bronchopulmonary Dysplasia"],"prefix":"10.1128","volume":"50","author":[{"given":"Matthew S.","family":"Payne","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Sciences, King's College London, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C. 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