{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:01:35Z","timestamp":1776333695604,"version":"3.51.2"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The triage of women with high-risk (HR) human papillomavirus (HPV)-positive smears for atypical squamous cells of undetermined significance (ASC-US) to colposcopy is now an integrated option in clinical guidelines. The performance of cobas 4800 HPV and that of Hybrid Capture 2 (HC2) for HR HPV DNA detection in cervical samples in PreservCyt were compared in 396 women referred to colposcopy for ASC-US. Of these, 316 did not have cervical intraepithelial neoplasia (CIN), 47 had CIN1, 29 had CIN2 or CIN3 (CIN2+), and 4 had CIN of unknown grade. HR HPV was detected in 129 (32.6%) and 149 (37.6%) samples with HC2 and cobas 4800 HPV, respectively (\n            <jats:italic>P<\/jats:italic>\n            = 0.15). The clinical sensitivities and specificities for detecting CIN2+ were 89.7% (95% confidence interval [CI], 72.8 to 97.2%) and 66.7% (95% CI, 61.7 to 71.3%) with cobas 4800 HPV and 93.1% (95% CI, 77.0 to 99.2%) and 72.2% (95% CI 67.4 to 76.5%) with HC2. The performance of cobas 4800 HPV was similar to that of HC2 for identifying women with ASC-US who would benefit the most from colposcopy.\n          <\/jats:p>","DOI":"10.1128\/jcm.06656-11","type":"journal-article","created":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T19:55:26Z","timestamp":1328212526000},"page":"1240-1244","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Human Papillomavirus (HPV) DNA Triage of Women with Atypical Squamous Cells of Undetermined Significance with cobas 4800 HPV and Hybrid Capture 2 Tests for Detection of High-Grade Lesions of the Uterine Cervix"],"prefix":"10.1128","volume":"50","author":[{"given":"Simon Grandjean","family":"Lapierre","sequence":"first","affiliation":[{"name":"D\u00e9partement de Microbiologie et Infectiologie and de Gyn\u00e9cologie-Obst\u00e9trique et Pathologie, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Sauthier","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie et Infectiologie and de Gyn\u00e9cologie-Obst\u00e9trique et Pathologie, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"D\u00e9partements de Microbiologie-Immunologie, de Gyn\u00e9cologie-Obst\u00e9trique, and de Pathologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Mayrand","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie et Infectiologie and de Gyn\u00e9cologie-Obst\u00e9trique et Pathologie, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"D\u00e9partements de Microbiologie-Immunologie, de Gyn\u00e9cologie-Obst\u00e9trique, and de Pathologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Dufresne","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie et Infectiologie and de Gyn\u00e9cologie-Obst\u00e9trique et Pathologie, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Petignat","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Oncogyn\u00e9cologie, H\u00f4pitaux Universitaires de Gen\u00e8ve, Gen\u00e8ve, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Provencher","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie et Infectiologie and de Gyn\u00e9cologie-Obst\u00e9trique et Pathologie, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"D\u00e9partements de Microbiologie-Immunologie, de Gyn\u00e9cologie-Obst\u00e9trique, and de Pathologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Drouin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie et Infectiologie and de Gyn\u00e9cologie-Obst\u00e9trique et Pathologie, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"D\u00e9partements de Microbiologie-Immunologie, de Gyn\u00e9cologie-Obst\u00e9trique, and de Pathologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Gauthier","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie et Infectiologie and de Gyn\u00e9cologie-Obst\u00e9trique et Pathologie, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"D\u00e9partements de Microbiologie-Immunologie, de Gyn\u00e9cologie-Obst\u00e9trique, and de Pathologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Jos\u00e9e","family":"Dupuis","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie et Infectiologie and de Gyn\u00e9cologie-Obst\u00e9trique et Pathologie, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"D\u00e9partements de Microbiologie-Immunologie, de Gyn\u00e9cologie-Obst\u00e9trique, and de Pathologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Michon","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie et Infectiologie and de 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