{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:49:25Z","timestamp":1791859765802,"version":"4.3.4"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1979,9,1]],"date-time":"1979-09-01T00:00:00Z","timestamp":304992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[1979,9]]},"abstract":"<jats:p>\n            Sera from 71 patients with culturally proven nocardiosis were tested for precipitins against a pool of\n            <jats:italic>Nocardia asteroides<\/jats:italic>\n            and\n            <jats:italic>N. brasiliensis<\/jats:italic>\n            culture filtrates and against antigens from the supernatant of homogenized\n            <jats:italic>N. asteroides<\/jats:italic>\n            cells. A human nocardiosis case serum was used as a reference. Sera from 56 of the 71 cases were reactive with either the culture filtrate antigen, the homogenate antigen, or both antigens, resulting in an overall sensitivity of 79%. Sera from 35 of the patients (49%) were positive with the homogenate antigens, and 28 (39%) showed bands of identity with the reference serum. Sera from 50 nocardiosis cases (70%) were positive with the pooled culture filtrate antigens, and 29 (41%) produced bands of identity with the reference serum. Of 89 sera from patients with various systemic mycotic diseases, tuberculosis, or actinomycosis, 24 (27%) were positive with the nocardial homogenate antigens and 4 (4.5%) showed precipitin bands of identity. Thirty-five of the 89 sera (42%) were positive with the nocardial culture filtrate antigens, and 6 (6.7%) showed bands of identity. The majority of sera demonstrating false-positive reactions were from tuberculosis and actinomycosis cases. One of seven sera from well individuals produced a precipitin band with the culture filtrate antigen, but this was not a band of identity with reference serum. These antigens did not distinguish antibodies from patients with\n            <jats:italic>N. asteroides, N. brasiliensis,<\/jats:italic>\n            or\n            <jats:italic>N. cavia<\/jats:italic>\n            infections.\n          <\/jats:p>","DOI":"10.1128\/jcm.10.3.308-312.1979","type":"journal-article","created":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T02:21:40Z","timestamp":1578190900000},"page":"308-312","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Microimmunodiffusion Test for Nocardiosis"],"prefix":"10.1128","volume":"10","author":[{"given":"Sharon O.","family":"Blumer","sequence":"first","affiliation":[{"name":"Mycology Division, Center for Disease Control, Atlanta, Georgia 30333"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Mycology Division, Center for Disease Control, Atlanta, Georgia 30333"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jcm.10.3.308-312.1979","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jcm.10.3.308-312.1979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T21:04:55Z","timestamp":1646427895000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jcm.10.3.308-312.1979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1979,9]]}},"alternative-id":["10.1128\/jcm.10.3.308-312.1979"],"URL":"https:\/\/doi.org\/10.1128\/jcm.10.3.308-312.1979","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,9]]},"assertion":[{"value":"1979-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}