{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:52:44Z","timestamp":1761897164664},"reference-count":0,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[1987,10,1]],"date-time":"1987-10-01T00:00:00Z","timestamp":560044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[1987,10]]},"abstract":"<jats:p>To better define the optimum timing of specimen collection and identify alternate ways to diagnose Norwalk virus outbreaks, we looked at the timing of the antibody response and virus excretion in a human volunteer study. The Norwalk virus antibody titers and antigen in stool specimens were examined by biotin-avidin immunoassay. Our data suggest that in epidemic situations, convalescent-phase sera could be collected as soon as 13 days after the onset of illness and acute-phase sera could be collected as late as 5 days after onset. Our data also suggest that if sufficient serum samples are collected, convalescent-phase case and control serum samples can be used to identify Norwalk virus outbreaks. Antigen detection was much less sensitive than seroconversion for detecting infection.<\/jats:p>","DOI":"10.1128\/jcm.25.10.2001-2003.1987","type":"journal-article","created":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T03:02:50Z","timestamp":1578193370000},"page":"2001-2003","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["Norwalk virus antigen and antibody response in an adult volunteer study"],"prefix":"10.1128","volume":"25","author":[{"given":"G W","family":"Gary","sequence":"first","affiliation":[{"name":"Respiratory and Enterovirus Branch, Centers for Disease Control, Atlanta, Georgia 30333."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L J","family":"Anderson","sequence":"additional","affiliation":[{"name":"Respiratory and Enterovirus Branch, Centers for Disease Control, Atlanta, Georgia 30333."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B H","family":"Keswick","sequence":"additional","affiliation":[{"name":"Respiratory and Enterovirus Branch, Centers for Disease Control, Atlanta, Georgia 30333."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P C","family":"Johnson","sequence":"additional","affiliation":[{"name":"Respiratory and Enterovirus Branch, Centers for Disease Control, Atlanta, Georgia 30333."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H L","family":"DuPont","sequence":"additional","affiliation":[{"name":"Respiratory and Enterovirus Branch, Centers for Disease Control, Atlanta, Georgia 30333."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S E","family":"Stine","sequence":"additional","affiliation":[{"name":"Respiratory and Enterovirus Branch, Centers for Disease Control, Atlanta, Georgia 30333."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A V","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Respiratory and Enterovirus Branch, Centers for Disease Control, Atlanta, Georgia 30333."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jcm.25.10.2001-2003.1987","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jcm.25.10.2001-2003.1987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T22:28:54Z","timestamp":1646432934000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jcm.25.10.2001-2003.1987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1987,10]]}},"alternative-id":["10.1128\/jcm.25.10.2001-2003.1987"],"URL":"https:\/\/doi.org\/10.1128\/jcm.25.10.2001-2003.1987","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,10]]},"assertion":[{"value":"1987-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}