{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:13:21Z","timestamp":1761156801453},"reference-count":37,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1998,2,1]],"date-time":"1998-02-01T00:00:00Z","timestamp":886291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[1998,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A prospective, multicenter study was carried out over a period of 10 months. All patients with clinically significant bacteremia caused by\n            <jats:italic>Enterococcus<\/jats:italic>\n            spp. were included. The epidemiological, microbiological, clinical, and prognostic features and the relationship of these features to the presence of high-level resistance to gentamicin (HLRG) were studied. Ninety-three patients with enterococcal bacteremia were included, and 31 of these cases were caused by HLRG (33%). The multivariate analysis selected chronic renal failure, intensive care unit stay, previous use of antimicrobial agents, and\n            <jats:italic>Enterococcus faecalis<\/jats:italic>\n            species as the independent risk factors that influenced the development of HLRG. The strains with HLRG showed lower levels of susceptibility to penicillin and ciprofloxacin. Clinical features (except for chronic renal failure) were similar in both groups of patients. HLRG did not influence the prognosis for patients with enterococcal bacteremia in terms of either the crude mortality rate (29% for patients with bacteremia caused by enterococci with HLRG and 28% for patients not infected with strains with HLRG) or the hospital stay after the acquisition of enterococcal bacteremia. Hemodynamic compromise, inappropriate antimicrobial therapy, and mechanical ventilation were revealed in the multivariate analysis to be the independent risk factors for mortality. Prolonged hospitalization was associated with the nosocomial acquisition of bacteremia and polymicrobial infections.\n          <\/jats:p>","DOI":"10.1128\/jcm.36.2.520-525.1998","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T17:26:40Z","timestamp":1577813200000},"page":"520-525","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":44,"title":["Comparative Study of Bacteremias Caused by\n            <i>Enterococcus<\/i>\n            spp. with and without High-Level Resistance to Gentamicin"],"prefix":"10.1128","volume":"36","author":[{"given":"Francisco Javier","family":"Caballero-Granado","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Unidad de Enfermedades Infecciosas, Hospital Universitario \u201cVirgen del Roc\u0131\u0301o,\u201d1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Cisneros","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Unidad de Enfermedades Infecciosas, Hospital Universitario \u201cVirgen del Roc\u0131\u0301o,\u201d1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Luque","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Servicio de Medicina Interna, Hospital de Motril, Motril,2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Torres-Tortosa","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Unidad de Enfermedades Infecciosas, Hospital \u201cPunta de Europa,\u201d Algeciras,3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Gamboa","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Unidad de Enfermedades Infecciosas, Hospital \u201cde Valme,\u201d Seville,4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Di\u0301ez","sequence":"additional","affiliation":[{"name":"<!--label omitted: 5-->Servicio de Medicina Interna, Hospital \u201cTorreca\u0301rdenas,\u201d Almer\u0131\u0301a,5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Villanueva","sequence":"additional","affiliation":[{"name":"<!--label omitted: 6-->Unidad de Enfermedades Infecciosas, Hospital \u201cReina Sofia,\u201d Co\u0301rdoba,6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Pe\u0301rez-Cano","sequence":"additional","affiliation":[{"name":"<!--label omitted: 7-->Servicio de Medicina Interna, Hospital \u201cPuerta del Mar,\u201d7 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pasquau","sequence":"additional","affiliation":[{"name":"<!--label omitted: 8-->Unidad de Enfermedades Infecciosas, Hospial Virgen de las Nieves,8Granada,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Merino","sequence":"additional","affiliation":[{"name":"<!--label omitted: 9-->Servicio de Medicina Interna, Hospital \u201cJuan Ramo\u0301n Jime\u0301nez,\u201d9 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Menchero","sequence":"additional","affiliation":[{"name":"<!--label omitted: 10-->Servicio de Medicina Interna, Hospital \u201cInfanta Elena,\u201d10 Huelva, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Mora","sequence":"additional","affiliation":[{"name":"<!--label omitted: 11-->Servicio de Medicina Interna, Hospital \u201cCarlos Haya,\u201d Ma\u0301laga,11 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Lo\u0301pez-Ruz","sequence":"additional","affiliation":[{"name":"<!--label omitted: 12-->Servicio de Medicina Interna, Hospital Cl\u0131\u0301nico de Granada,12 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Vergara","sequence":"additional","affiliation":[{"name":"<!--label omitted: 13-->Servicio de Medicina Interna, Hospital de Puerto Real, Puerto Real,13 Ca\u0301diz,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"for the Grupo Andaluz Para El Estudio De Las Enfermedades","family":"Infecciosas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1644"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/13.6.1248"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.1.103"},{"key":"e_1_3_1_5_2","first-page":"455","article-title":"Enterococos aislados en sangre (1989\u20131993): evoluci\u00f3n de la susceptibilidad a los antibi\u00f3ticos","volume":"13","author":"Balas D.","year":"1995","unstructured":"Balas D. 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