{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:21:39Z","timestamp":1789392099155,"version":"build-2803163510"},"reference-count":69,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The spotted fever group (SFG) is made up of more than 20 different rickettsial species and strains. Study of the taxonomic relationships among the group has been attempted by phenotypic, genotypic, and phylogenetic analyses. In this study, we determined taxonomic relationships among the SFG rickettsiae by comparative analysis of immunogenic epitopes reactive against a panel of monoclonal antibodies. A total of 98 monoclonal antibodies, which were directed against epitopes on the major immunodominant proteins or on the lipopolysaccharide-like antigens of strains of<jats:italic>Rickettsia africae<\/jats:italic>,<jats:italic>Rickettsia conorii<\/jats:italic>,<jats:italic>Rickettsia massiliae<\/jats:italic>,<jats:italic>Rickettsia akari<\/jats:italic>,<jats:italic>Rickettsia sibirica<\/jats:italic>, and<jats:italic>Rickettsia slovaca<\/jats:italic>, were used in the study. The distribution and expression of the epitopes among 29 SFG rickettsiae and<jats:italic>Rickettsia bellii<\/jats:italic>were assessed by determination of reaction titers in a microimmunofluorescence assay. The results were scored as numerical taxonomic data, and cluster analysis was used to construct a dendrogram. The architecture of this dendrogram was consistent with previous taxonomic studies, and the implications of this and other findings are discussed.<\/jats:p>","DOI":"10.1128\/jcm.36.4.887-896.1998","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T17:29:07Z","timestamp":1577813347000},"page":"887-896","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Taxonomic Relationships among Spotted Fever Group Rickettsiae as Revealed by Antigenic Analysis with Monoclonal Antibodies"],"prefix":"10.1128","volume":"36","author":[{"given":"Wenbin","family":"Xu","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Unite\u0301 des Rickettsies, CNRS UPRES-A 6020, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Mediterrane\u0301e, 13385 Marseille Ce\u0301dex 5, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Unite\u0301 des Rickettsies, CNRS UPRES-A 6020, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Mediterrane\u0301e, 13385 Marseille Ce\u0301dex 5, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/151.6.1052"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.51.2.653-660.1986"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.25.1.167-171.1987"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.58.9.2760-2769.1990"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1946.tb34304.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1994.50.365"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.6.1526-1530.1996"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.8.1922-1930.1992"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-47-2-548"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-43-3-521"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-43-4-839"},{"key":"e_1_3_2_13_2","unstructured":"Beati L. Raoult D. Spotted fever group rickettsiae Rickettsiae and rickettsial diseases. Proceedings of the Vth International Symposium 1996 Slovak Academy of Sciences. Kazar J. Toman R. 1996 134 178 Slovak Academy of Sciences Bratislava Slovakia"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.11.2688-2694.1996"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.4049\/jimmunol.90.5.770","article-title":"Nonpathogenic rickettsias related to the spotted fever group isolated from the ticks, Dermacentor variabilis and Dermacentor andersoni from eastern Montana","volume":"90","author":"Bell E. J.","year":"1963","unstructured":"Bell E. J. Kohls G. M. Stoenner H. G. Lackman D. B. Nonpathogenic rickettsias related to the spotted fever group isolated from the ticks, Dermacentor variabilis and Dermacentor andersoni from eastern Montana.J. Immunol. 90 1963 770 781","journal-title":"J. Immunol."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.4049\/jimmunol.70.5.461","article-title":"A toxic substance associated with the rickettsias of the SFG","volume":"70","author":"Bell E. J.","year":"1953","unstructured":"Bell E. J. Pickens E. G. A toxic substance associated with the rickettsias of the SFG.J. Immunol. 70 1953 461 472","journal-title":"J. Immunol."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4049\/jimmunol.84.2.171","article-title":"Immunologic relationships among the spotted fever group of rickettsias determined by toxin neutralisation tests in mice with convalescent animal serums","volume":"84","author":"Bell E. J.","year":"1960","unstructured":"Bell E. J. Stoenner H. G. Immunologic relationships among the spotted fever group of rickettsias determined by toxin neutralisation tests in mice with convalescent animal serums.J. Immunol. 84 1960 171 182","journal-title":"J. Immunol."},{"key":"e_1_3_2_18_2","first-page":"563","article-title":"A search for the epidemic typhus agent in Ethiopian ticks","volume":"48","author":"Burgdorfer W.","year":"1973","unstructured":"Burgdorfer W. Ormsbee R. A. Schmidt M. L. Hoogstraal H. A search for the epidemic typhus agent in Ethiopian ticks.Bull. W. H. O. 48 1973 563 569","journal-title":"Bull. W. H. O."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.12.1.205-210.1975"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb42244.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/165.6.1167"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.3.803-810.1994"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.10.2738-2744.1995"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1994.51.697"},{"key":"e_1_3_2_25_2","unstructured":"Fournier P.-E. V. Roux and D. Raoult. Phylogenetic analysis of spotted fever group rickettsiae by study of the outer surface protein rOmpA. Submitted for publication."},{"key":"e_1_3_2_26_2","first-page":"101","article-title":"Other spotted fever group rickettsioses: clinical signs, symptoms, and pathology","volume":"1","author":"Gear J. H. S.","year":"1988","unstructured":"Gear J. H. S. Other spotted fever group rickettsioses: clinical signs, symptoms, and pathology Biology of rickettsial diseases Walker D. H. 1 1988 101 115 CRC Press, Inc. Boca Raton, Fla","journal-title":"Biology of rickettsial diseases"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(93)90752-O"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1991.tb02082.x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(91)90027-7"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/10520296409061219"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.3109\/inf.1974.6.issue-1.10"},{"key":"e_1_3_2_32_2","first-page":"13","article-title":"A propos de la diff\u00e9renciation de quelques rickettsies du groupe de la fi\u00e8vre pourpr\u00e9e \u00e0 tiques","volume":"37","author":"Golinevitch H.","year":"1960","unstructured":"Golinevitch H. A propos de la diff\u00e9renciation de quelques rickettsies du groupe de la fi\u00e8vre pourpr\u00e9e \u00e0 tiques.Inst. Pasteur Tunis 37 1960 13 22","journal-title":"Inst. Pasteur Tunis"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0147-9571(93)90149-Y"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.2307\/4585895"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1992.tb01845.x"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-46-2-611"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.56.10.2587-2593.1988"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.10.2653-2656.1992"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-47-2-446"},{"key":"e_1_3_2_40_2","unstructured":"Philip C. B. Hughes L. E. Rao K. N. A. Katra L. Studies on Indian tick typhus and its relation to other human typhus-like rickettsiosis Archives of the 5th International Congress for Microbiology 17 to 24 August 1950 Rio de Janeiro Brazil 1958 115"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-33-1-94"},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.4049\/jimmunol.121.5.1961","article-title":"Serologic typing of rickettsiae of the spotted fever group by microimmunofluorescence","volume":"121","author":"Philip R. N.","year":"1978","unstructured":"Philip R. N. Casper E. A. Burgdorfer W. Gerloff R. K. Hughes L. B. Bell E. J. Serologic typing of rickettsiae of the spotted fever group by microimmunofluorescence.J. Immunol. 121 1978 1961 1968","journal-title":"J. Immunol."},{"key":"e_1_3_2_43_2","first-page":"388","article-title":"Etude exp\u00e9rimentale compar\u00e9e de la fi\u00e8vre boutonneuse et de la tick-bite fever","volume":"25","author":"Pijper A.","year":"1936","unstructured":"Pijper A. Etude exp\u00e9rimentale compar\u00e9e de la fi\u00e8vre boutonneuse et de la tick-bite fever.Arch. Inst. Pasteur Tunisia 25 1936 388 401","journal-title":"Arch. Inst. Pasteur Tunisia"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-55-14506"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.4.694"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.5.1576-1589.1991"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a121485"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.9.2058-2065.1996"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.15.4895-4904.1993"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2508(96)80284-1"},{"key":"e_1_3_2_51_2","unstructured":"Roux V. and D. Raoult. Unpublished data."},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-47-2-252"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.51.5.873-884.1986"},{"key":"e_1_3_2_54_2","unstructured":"Sneath P. H. A. Sokal R. R. Numerical taxonomy The principles and practice of numerical classification. W. H. 1973 230 234 Freeman & Co. San Francisco Calif"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.2307\/4579569"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.1.261-263.1997"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0723-2020(11)80448-0"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-42-2-303"},{"key":"e_1_3_2_59_2","unstructured":"Urvolgyi J. Brezina R. Rickettsia slovaca : a new number of spotted fever group rickettsiae Rickettsiae and rickettsial diseases. Proceedings of the Second International Symposium 1976 Kazar J. Ormsbee R. A. Tarasevich I. V. 1978 299 305 Slovak Academy of Sciences Slovak Academy of Sciences. Bratislava Slovakia"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1991.tb04783.x"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1995.52.569"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1992.47.78"},{"key":"e_1_3_2_63_2","unstructured":"Walker D. H. Raoult D. Rickettsia rickettsii and other spotted fever group rickettsiae (Rocky Mountain spotted fever and other spotted fever) Principles and practice of infectious diseases 4th ed. Mandell G. L. Bennett J. E. Dolin R. 1995 1721 1727 Churchill Livingstone Inc. New York N.Y"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.36.100182.002021"},{"key":"e_1_3_2_65_2","first-page":"271","article-title":"Biochemistry of rickettsiae: recent advances","volume":"31","author":"Weiss E.","year":"1987","unstructured":"Weiss E. Dobson M. E. Dasch G. A. Biochemistry of rickettsiae: recent advances.Acta Virol. 31 1987 271 286","journal-title":"Acta Virol."},{"key":"e_1_3_2_66_2","first-page":"687","article-title":"Order I. Rickettsiales Gieszczkiewicz 1939, 25AL","volume":"1","author":"Weiss E.","year":"1984","unstructured":"Weiss E. Moulder J. W. Order I. Rickettsiales Gieszczkiewicz 1939, 25AL Bergey\u2019s manual of systematic bacteriology Krieg N. R. Holt J. G. 1 1984 687 701 The Williams and Wilkins Co. Baltimore, Md","journal-title":"Bergey\u2019s manual of systematic bacteriology"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.1.64-70.1997"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.7.1715-1721.1997"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.4.6.753-763.1997"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.1.83-88.1993"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.36.4.887-896.1998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.36.4.887-896.1998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:53:35Z","timestamp":1695567215000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.36.4.887-896.1998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,4]]}},"alternative-id":["10.1128\/JCM.36.4.887-896.1998"],"URL":"https:\/\/doi.org\/10.1128\/jcm.36.4.887-896.1998","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,4]]},"assertion":[{"value":"1997-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-01-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}