{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:41:40Z","timestamp":1761129700506},"reference-count":27,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[1999,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Although\n            <jats:italic>Candida albicans<\/jats:italic>\n            remains the fungal species most frequently isolated as an opportunistic oral pathogen, other yeast species are often identified in human immunodeficiency virus (HIV)-seropositive patients.\n            <jats:italic>Candida dubliniensis<\/jats:italic>\n            phenotypically resembles\n            <jats:italic>C. albicans<\/jats:italic>\n            in many respects, yet it can be identified and differentiated as a unique\n            <jats:italic>Candida<\/jats:italic>\n            species by its phenotypic and genetic profiles. The purpose of the present study was to prospectively test for the presence of\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            among clinical isolates and to determine the clinical and demographic characteristics of patients harboring\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            . Over a 90-day period, isolates from 724 patients that were presumptively identified as\n            <jats:italic>C. albicans<\/jats:italic>\n            were screened for\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            by use of tests for germ tube and chlamydospore production, by detection of an inability to grow at 45\u00b0C, by colony color on CHROMagar Candida medium, and by the results of a sugar assimilation test with the API 20C AUX yeast identification system. Among 699 isolates retrieved from those specimens evaluated, 5 from 25 HIV-seropositive patients and 1 isolate from a patient whose HIV status was unknown were shown to be consistent by phenotyping and by electrophoretic karyotyping with the European reference strain of\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            . One of the\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            isolates had dose-dependent susceptibility to fluconazole (MIC, 16 \u03bcg\/ml). These results confirm the presence of this interesting species in the United States and support the need for further investigations into the prevalence and pathogenesis of\n            <jats:italic>C. dubliniensis.<\/jats:italic>\n          <\/jats:p>","DOI":"10.1128\/jcm.37.2.321-326.1999","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T17:42:24Z","timestamp":1577814144000},"page":"321-326","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":85,"title":["Identification of\n            <i>Candida dubliniensis<\/i>\n            in a Prospective Study of Patients in the United States"],"prefix":"10.1128","volume":"37","author":[{"given":"Mary Ann","family":"Jabra-Rizk","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Oral Medicine1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A. M. A.","family":"Baqui","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Oral Medicine1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline I.","family":"Kelley","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Oral Medicine1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"William A.","family":"Falkler","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of OCBS,2 Dental School, University of Maryland, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Merz","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Department of Pathology, The Johns Hopkins University,3 Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy F.","family":"Meiller","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Oral Medicine1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.5.1129-1135.1995"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199705000-00002"},{"key":"e_1_3_2_4_2","unstructured":"Elie\nC. 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Document M27-A.\n1997\nNational Committee for Clinical Laboratory Standards\nWayne Pa"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.8.1923-1929.1994"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.10.2869-2873.1998"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.7.2093-2095.1998"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.2.235"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.5.1467-1467.1998"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01695634"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.8.2124-2133.1993"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-141-7-1507"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.4.960-964.1997"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.2.329-334.1998"},{"key":"e_1_3_2_24_2","unstructured":"Sullivan\nD. 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N.\n1995\n723\n737\nASM Press\nWashington D.C"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-91-4-539"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110313251803"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.37.2.321-326.1999","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.37.2.321-326.1999","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T23:58:50Z","timestamp":1646438330000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.37.2.321-326.1999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,2]]}},"alternative-id":["10.1128\/JCM.37.2.321-326.1999"],"URL":"https:\/\/doi.org\/10.1128\/jcm.37.2.321-326.1999","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,2]]},"assertion":[{"value":"1998-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}