{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:01:15Z","timestamp":1769839275894,"version":"3.49.0"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[1999,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A total of 122\n            <jats:italic>Streptococcus suis<\/jats:italic>\n            serotype 2 strains were characterized thoroughly by comparing clinical and pathological observations, ribotype profiles, and antimicrobial resistance. Twenty-one different ribotype profiles were found and compared by cluster analysis, resulting in the identification of three ribotype clusters. A total of 58% of all strains investigated were of two ribotypes belonging to different ribotype clusters. A remarkable relationship existed between the observed ribotype profiles and the clinical-pathological observations because strains of one of the two dominant ribotypes were almost exclusively isolated from pigs with meningitis, while strains of the other dominant ribotype were never associated with meningitis. This second ribotype was isolated only from pigs with pneumonia, endocarditis, pericarditis, or septicemia. Cluster analysis revealed that strains belonging to the same ribotype cluster as one of the dominant ribotypes came from pigs that showed clinical signs similar to those of pigs infected with strains with the respective dominant ribotype profiles. Furthermore, strains belonging to different ribotype clusters had totally different patterns of resistance to antibiotics because strains isolated from pigs with meningitis were resistant to sulfamethazoxazole and strains isolated from pigs with pneumonia, endocarditis, pericarditis, or septicemia were resistant to tetracycline.\n          <\/jats:p>","DOI":"10.1128\/jcm.37.2.404-408.1999","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T17:42:34Z","timestamp":1577814154000},"page":"404-408","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Associations of\n            <i>Streptococcus suis<\/i>\n            Serotype 2 Ribotype Profiles with Clinical Disease and Antimicrobial Resistance"],"prefix":"10.1128","volume":"37","author":[{"given":"S. R.","family":"Rasmussen","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Danish Veterinary Laboratory, DK-1790 Copenhagen V, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. M.","family":"Aarestrup","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Danish Veterinary Laboratory, DK-1790 Copenhagen V, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. E.","family":"Jensen","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Danish Veterinary Laboratory, DK-1790 Copenhagen V, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. E.","family":"Jorsal","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Danish Veterinary Laboratory, DK-1790 Copenhagen V, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(98)00147-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(98)00228-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.6.1595-1596.1997"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-138-12-2639"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-37-3-162"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1935(17)30581-X"},{"key":"e_1_3_2_8_2","unstructured":"Clifton-Hadley\nF. A.\nThe epidemiology diagnosis treatment and control of Streptococcus suis type 2 infections\nProceedings of the American Association of Swine Practitioners.\n1986\n471\n491\nAmerican Association of Swine Practitioners\nPerry Iowa"},{"key":"e_1_3_2_9_2","unstructured":"Danish Veterinary Laboratory and Danish Veterinary Institute for Virus Research\nThe 1996 annual report.\n1996\nDVL and DVIV\nCopenhagen Denmark"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.27.12.2633-2636.1989"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.11.2590-2594.1991"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(92)90094-A"},{"key":"e_1_3_2_13_2","first-page":"259","article-title":"Genomic relatedness among reference strains of different Streptococcus suis serotypes","volume":"58","author":"Harel J.","year":"1994","unstructured":"Harel J. Higgins R. Gottschalk M. G. Bigras-Ppoulin M. 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E.\nVecht\nU.\nWisselink\nH. J.\nStockhofe-Zurwieden\nN. Streptococcus suis mutants in which the genes muramidase-released protein (MRP) and extracellular protein factor (EF) are inactivated are virulent for pigs.Proceedings of the 14th IPVS Congress1996"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.5.1049-1053.1997"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.1.15-19.1998"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.9.3659-3665.1996"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800058362"},{"key":"e_1_3_2_29_2","first-page":"1037","article-title":"Differences in virulence between two strains of Streptococcus suis type 2 after experimentally induced infection of newborn germ-free pigs","volume":"50","author":"Vecht U.","year":"1989","unstructured":"Vecht U. Arends J. P. van der Molen E. J. van Leengoed L. A. M. 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