{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T22:51:34Z","timestamp":1770677494374,"version":"3.49.0"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A potential virulence determinant of\n            <jats:italic>Helicobacter pylori<\/jats:italic>\n            is the\n            <jats:italic>cagA<\/jats:italic>\n            gene product. To determine the relevance of the expression of CagA to the clinical picture and outcome of\n            <jats:italic>H. pylori<\/jats:italic>\n            infection in children, we examined 104 consecutive children diagnosed with\n            <jats:italic>H. pylori<\/jats:italic>\n            infection. Serum samples were collected to test for the presence of immunoglobulin G (IgG) anti-CagA antibodies. Forty-five patients (43%) had antibodies to the CagA protein (group I), and 59 did not (group II). Seropositive patients had a longer prediagnostic history of abdominal pain (\n            <jats:italic>P<\/jats:italic>\n            = 0.02), more severe abdominal pain (defined as ulcer pain) (\n            <jats:italic>P<\/jats:italic>\n            = 0.05), a higher prevalence of duodenal ulcer (38 versus 7%;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01), more active chronic gastritis (82 versus 32%;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001), and a higher titer of serum IgG anti-\n            <jats:italic>H. pylori<\/jats:italic>\n            antibodies (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). Ninety percent of the patients were monitored for 27 \u00b1 18 months. On multivariate analysis, CagA-negative patients had a 3.8-fold-higher chance of achieving a disease-free state than CagA-positive patients (95% confidence interval, 1.5- to 9.5-fold). We conclude that infection with CagA-producing strains of\n            <jats:italic>H. pylori<\/jats:italic>\n            is a risk factor for severe clinical disease and ongoing infection.\n          <\/jats:p>","DOI":"10.1128\/jcm.38.10.3534-3537.2000","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T17:49:33Z","timestamp":1577814573000},"page":"3534-3537","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Relevance of CagA Positivity to Clinical Course of\n            <i>Helicobacter pylori<\/i>\n            Infection in Children"],"prefix":"10.1128","volume":"38","author":[{"given":"J.","family":"Yahav","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Helicobacter Research Center, Rabin Medical Center, Beilinson Campus, Petah Tiqva,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fradkin","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Pediatric Gastroenterology Unit, Chaim Sheba Medical Center, Tel Hashomer,2 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Weisselberg","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Pediatric Gastroenterology Unit, Chaim Sheba Medical Center, Tel Hashomer,2 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Diver-Haver","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Pediatric Gastroenterology Unit, Chaim Sheba Medical Center, Tel Hashomer,2 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Shmuely","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Helicobacter Research Center, Rabin Medical Center, Beilinson Campus, Petah Tiqva,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Jonas","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Pediatric Gastroenterology Unit, Chaim Sheba Medical Center, Tel Hashomer,2 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92020-5"},{"key":"e_1_3_1_3_2","first-page":"2111","article-title":"Infection with Helicobacter pylori strains possessing CagA is associated with an increased risk of developing adenocarcinoma of the stomach","volume":"55","author":"Blaser M. 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