{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:00:10Z","timestamp":1791036010947,"version":"4.1.0"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2000,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n In a search for methods for subtyping of\n Bartonella henselae<\/jats:italic>\n in clinical samples, we amplified and sequenced a 701-bp region in the 3\u2032 end of the\n ftsZ<\/jats:italic>\n gene in 15\n B. henselae<\/jats:italic>\n isolates derived from cats and humans in the United States and Europe. The\n ftsZ<\/jats:italic>\n sequence variants that were discovered were designated variants Bh\n ftsZ<\/jats:italic>\n 1, 2, and 3 and were compared with 16S rRNA genotypes I and II of the same isolates. There was no\n ftsZ<\/jats:italic>\n gene variation in the strains of 16S rRNA type I, all of which were Bh\n ftsZ<\/jats:italic>\n 1. The type II strains constituted two groups, with nucleotide sequence variation in the\n ftsZ<\/jats:italic>\n gene resulting in amino acid substitutions at three positions, one of which was shared by the two groups. One 16S rRNA type II isolate had an\n ftsZ<\/jats:italic>\n gene sequence identical to those of the type I strains. Variants Bh\n ftsZ<\/jats:italic>\n 1 and 2 were detected in tissue specimens from seven Swedish patients with diagnoses such as chronic multifocal osteomyelitis, cardiomyopathy, and lymphadenopathy. Patients with similar clinical entities displayed either Bh\n ftsZ<\/jats:italic>\n variant. The etiological role of\n B. henselae<\/jats:italic>\n in these patients was supported by positive\n Bartonella<\/jats:italic>\n antibody titers and\/or amplification and sequencing of a part of the\n B. henselae gltA<\/jats:italic>\n gene.\n B. henselae ftsZ<\/jats:italic>\n gene sequence variation may be useful in providing knowledge about the epidemiology of various\n B. henselae<\/jats:italic>\n strains in clinical samples, especially when isolation attempts have failed. This report also describes manifestations of atypical\n Bartonella<\/jats:italic>\n infections in Sweden.\n <\/jats:p>","DOI":"10.1128\/jcm.38.2.682-687.2000","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T17:52:47Z","timestamp":1577814767000},"page":"682-687","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["Sequence Variation in the\n ftsZ<\/i>\n Gene of\n Bartonella henselae<\/i>\n Isolates and Clinical Samples"],"prefix":"10.1128","volume":"38","author":[{"given":"C.","family":"Ehrenborg","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases, Department of Medical Sciences,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Wessle\u0301n","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Medical Sciences,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u212b.","family":"Jakobson","sequence":"additional","affiliation":[{"name":"Section of Pediatrics, Department of Women's and Children's Health,2 Uppsala University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Friman","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Medical Sciences,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Medical Sciences,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.4.942-948.1994"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.2.203"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.2.254-260.1996"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901213400303"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1999.tb01567.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.4.872-881.1993"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90012-4"},{"key":"e_1_3_2_10_2","first-page":"543","article-title":"SEAVIEW and PHYLO_WIN: two graphic tools for sequence alignment and molecular phylogeny","volume":"12","author":"Galtier N.","year":"1996","unstructured":"Galtier N. 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