{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T07:34:21Z","timestamp":1794468861374,"version":"4.9.1"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The production of toxic shock syndrome toxin 1 (TSST-1) by\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    MN8 exposed to a range of oxygen concentrations (0 to 21% [vol\/vol]) was examined in batch and thin-film cultures. The response of\n                    <jats:italic>S. aureus<\/jats:italic>\n                    to this range of oxygen concentrations was studied in the absence and in the presence of 7% (vol\/vol) carbon dioxide. In the absence of carbon dioxide, TSST-1 production in batch cultures increased from negligible levels in the presence of oxygen concentrations of 1% or less to 500 ng\/ml in the presence of 2% oxygen and then decreased to 70 ng\/ml or less in the presence of oxygen concentrations of 6% and higher. In the presence of carbon dioxide, however, toxin production increased from negligible levels in the presence of 1% oxygen to 1,900 ng\/ml in the presence of 21% oxygen. In thin-film cultures, TSST-1 production increased from nearly undetectable levels under anaerobic conditions to 1 and 10 \u03bcg\/ml under 21% oxygen in the absence and presence of carbon dioxide, respectively. This study demonstrates the controlling effects of both oxygen and carbon dioxide on TSST-1 production.\n                  <\/jats:p>","DOI":"10.1128\/jcm.38.5.1797-1803.2000","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T12:56:09Z","timestamp":1577796969000},"page":"1797-1803","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":78,"title":["Oxygen and Carbon Dioxide Regulation of Toxic Shock Syndrome Toxin 1 Production by\n                    <i>Staphylococcus aureus<\/i>\n                    MN8"],"prefix":"10.1128","volume":"38","author":[{"given":"Jeremy M.","family":"Yarwood","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Schlievert","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.9.5317"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91241-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(88)65009-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408419009105728"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/165.4.638"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.44.6.1349-1355.1982"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.4.812"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9803572"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2185544"},{"key":"e_1_3_2_13_2","unstructured":"Meissner\nH. C.\nLeung\nD. Y. M.\nKawasaki syndrome\nInfectious diseases.\nGorbach\nS. L.\nBartlett\nJ. G.\nBlackow\nN. R.\n1998\n1662\n1666\nThe W. B. Saunders Co.\nPhiladelphia Pa"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","unstructured":"Mishell\nB. B.\nMishell\nR. I.\nPrimary immunization in suspension cultures\nSelected methods in cellular immunology. W. H.\nMishell\nB. B.\nShiigi\nS. M.\n1980\n30\n37\nFreeman & Co.\nSan Francisco Calif","DOI":"10.2307\/1308350"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.13.3796-3802.1996"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-24-1-75"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(88)65050-6"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/147.2.236"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.3.626"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198012183032502"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.5.1374-1385.1996"},{"key":"e_1_3_2_22_2","first-page":"719","article-title":"Effect of dilution rate and Mg2+ limitation on toxic shock syndrome toxin-1 production by Staphylococcus aureus grown in defined continuous culture","volume":"134","author":"Taylor D.","year":"1988","unstructured":"Taylor D. Holland K. T. Effect of dilution rate and Mg2+ limitation on toxic shock syndrome toxin-1 production by Staphylococcus aureus grown in defined continuous culture.J. Gen. Microbiol.1341988719723","journal-title":"J. Gen. Microbiol."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.4.673"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)80165-9"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.58.4.1026-1029.1990"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.38.5.1797-1803.2000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.38.5.1797-1803.2000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T19:33:59Z","timestamp":1646422439000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.38.5.1797-1803.2000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["10.1128\/JCM.38.5.1797-1803.2000"],"URL":"https:\/\/doi.org\/10.1128\/jcm.38.5.1797-1803.2000","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]},"assertion":[{"value":"1999-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-02-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}