{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T01:51:47Z","timestamp":1778118707332,"version":"3.51.4"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            To determine whether certain\n            <jats:italic>Chlamydia trachomatis<\/jats:italic>\n            serovars are preferentially associated with a symptomatic or an asymptomatic course of infection,\n            <jats:italic>C. trachomatis<\/jats:italic>\n            serovar distributions were analyzed in symptomatically and asymptomatically infected persons. Furthermore, a possible association between\n            <jats:italic>C. trachomatis<\/jats:italic>\n            serovars and specific clinical symptoms was investigated.\n            <jats:italic>C. trachomatis<\/jats:italic>\n            -positive urine specimens from 219 asymptomatically infected men and women were obtained from population-based screening programs in Amsterdam. Two hundred twenty-one\n            <jats:italic>C. trachomatis<\/jats:italic>\n            -positive cervical and urethral swabs from symptomatically and asymptomatically infected men and women were obtained from several hospital-based departments. Serovars were determined using PCR-based genotyping, i.e., restriction fragment length polymorphism analysis of the nested-PCR-amplified\n            <jats:italic>omp1<\/jats:italic>\n            gene. The most prevalent\n            <jats:italic>C. trachomatis<\/jats:italic>\n            serovars, D, E, and F, showed no association with either a symptomatic or asymptomatic course of infection. The most prominent differences found were (i) the association of serovar Ga with symptoms in men (\n            <jats:italic>P<\/jats:italic>\n            = 0.0027), specifically, dysuria (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.0001), and (ii) detection of serovar Ia more often in asymptomatically infected people (men and women) (\n            <jats:italic>P<\/jats:italic>\n            = 0.035). Furthermore, in women, serovar K was associated with vaginal discharge (\n            <jats:italic>P<\/jats:italic>\n            = 0.002) and serovar variants were found only in women (\n            <jats:italic>P<\/jats:italic>\n            = 0.045).\n          <\/jats:p>","DOI":"10.1128\/jcm.38.6.2292-2296.2000","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T19:47:23Z","timestamp":1583783243000},"page":"2292-2296","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":98,"title":["Urogenital\n            <i>Chlamydia trachomatis<\/i>\n            Serovars in Men and Women with a Symptomatic or Asymptomatic Infection: an Association with Clinical Manifestations?"],"prefix":"10.1128","volume":"38","author":[{"given":"S. A.","family":"Morre\u0301","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology, Section of Molecular Pathology, University Hospital Vrije Universiteit,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Rozendaal","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology, Section of Molecular Pathology, University Hospital Vrije Universiteit,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. G. M.","family":"van Valkengoed","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Institute for Research in Extramural Medicine,2 Vrije Universiteit,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J. P.","family":"Boeke","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Institute for Research in Extramural Medicine,2 Vrije Universiteit,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. C.","family":"van Voorst Vader","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->STD Clinic, Department of Dermatology, University Hospital,3 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Schirm","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Regional Public Health Laboratory,4 Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"de Blok","sequence":"additional","affiliation":[{"name":"<!--label omitted: 5-->Department of Obstetrics and Gynecology, OLVG Hospital,5 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A. R.","family":"van den Hoek","sequence":"additional","affiliation":[{"name":"<!--label omitted: 6-->Municipal Health Service,6 Amsterdam, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. J. J.","family":"van Doornum","sequence":"additional","affiliation":[{"name":"<!--label omitted: 6-->Municipal Health Service,6 Amsterdam, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J. L. M.","family":"Meijer","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology, Section of Molecular Pathology, University Hospital Vrije Universiteit,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J. C.","family":"van den Brule","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology, Section of Molecular Pathology, University Hospital Vrije Universiteit,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.22.4.609-613.1985"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/156.6.953"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/152.5.985"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/160.2.332"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01972006"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119182"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.4.1013"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/163.5.1103"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.41.2.865-868.1983"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.1.213-219.1993"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.2.589"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.12.3194-3197.1995"},{"key":"e_1_3_2_14_2","first-page":"299","article-title":"Genotyping of Chlamydia trachomatis serovars derived from heterosexual partners and a detailed genomic analysis of serovar F","volume":"71","author":"Lan J.","year":"1995","unstructured":"Lan J. van den Hoek A. 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