{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:54:54Z","timestamp":1791424494558,"version":"4.3.3"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            From November 1998 to February 1999 we prospectively evaluated the prevalence of resistance to penicillins, cephalosporins, carbapenem, quinolones, aminoglycosides, and trimethoprim-sulfamethoxazole (SXT) in 320\n            <jats:italic>Escherichia coli<\/jats:italic>\n            isolates isolated from hospitalized patients with acute urinary tract infections (UTIs). We also studied for these strains risk factors for resistance to amoxicillin-clavulanic acid (AMC), fluoroquinolones (FQs), and SXT. Resistance rates were consistent with those from major recent studies reported in the literature. Multivariate analyses selected the following factors as being significantly associated with\n            <jats:italic>E. coli<\/jats:italic>\n            resistance: (i) for resistance to AMC, prior (1 year) UTI (odds ratio [OR] = 2.71,\n            <jats:italic>P<\/jats:italic>\n            = 0.006), prior (1 year) urinary catheter (OR = 2.98,\n            <jats:italic>P<\/jats:italic>\n            = 0.0025), and prior (6 months) antibiotic exposure (OR = 2.68,\n            <jats:italic>P<\/jats:italic>\n            = 0.005); (ii) for resistance to FQs male sex (OR = 3.87,\n            <jats:italic>P<\/jats:italic>\n            = 0.03), with a trend toward significance for age &gt;65 years (OR = 7.67,\n            <jats:italic>P<\/jats:italic>\n            = 0.06) and prior (1 year) UTI (OR = 2.98,\n            <jats:italic>P<\/jats:italic>\n            = 0.07); and (iii) for resistance to SXT, male sex (OR = 1.91,\n            <jats:italic>P<\/jats:italic>\n            = 0.046), hospitalization in an intermediate-term-care unit (OR = 2.18,\n            <jats:italic>P<\/jats:italic>\n            = 0.008), and prior (1 year) UTI (OR = 2.03,\n            <jats:italic>P<\/jats:italic>\n            = 0.03). Ours results suggest that prior UTI is a common risk factor for resistance to the different antibiotics tested. Although few studies on risk factors for\n            <jats:italic>E. coli<\/jats:italic>\n            resistance to antibiotics have been published, careful interpretation of their findings, taking into consideration the population, infection site, and period studied, should contribute to the formulation of a better strategy that can be used to overcome antibiotic resistance.\n          <\/jats:p>","DOI":"10.1128\/jcm.39.2.438-444.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:03:40Z","timestamp":1027764220000},"page":"438-444","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":84,"title":["Risk Factors for Antibiotic-Resistant\n            <i>Escherichia coli<\/i>\n            Isolated from Hospitalized Patients with Urinary Tract Infections: a Prospective Study"],"prefix":"10.1128","volume":"39","author":[{"given":"Albert","family":"Sotto","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire Universitaire de The\u0301rapeutique, Service de Me\u0301decine Interne B, Ho\u0302pital Care\u0301meau,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne Merle","family":"De Boever","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire Universitaire de The\u0301rapeutique, Service de Me\u0301decine Interne B, Ho\u0302pital Care\u0301meau,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Fabbro-Peray","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->De\u0301partement d'Information Me\u0301dicale2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Gouby","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Laboratoire de Microbiologie,3Ho\u0302pital Gaston-Doumergue, 30029 N\u0131\u0302mes Ce\u0301dex, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Sirot","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Laboratoire de Bacte\u0301riologie, Faculte\u0301 de Me\u0301decine, 63001 Clermont-Ferrand Cedex,4France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Jourdan","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire Universitaire de The\u0301rapeutique, Service de Me\u0301decine Interne B, Ho\u0302pital Care\u0301meau,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","first-page":"1436","article-title":"Risk factors for resistance to \u201cfirst-line\u201d antimicrobials among urinary tract isolates of Escherichia coli in children","volume":"160","author":"Allen U. 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