{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:51:44Z","timestamp":1768783904892,"version":"3.49.0"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Six isolates of\n            <jats:italic>Mycobacterium avium<\/jats:italic>\n            of genotype\n            <jats:italic>dnaJ<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            IS\n            <jats:italic>901<\/jats:italic>\n            <jats:sup>\u2212<\/jats:sup>\n            IS\n            <jats:italic>1311<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            IS\n            <jats:italic>1245<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            and serotypes 6 (\n            <jats:italic>n<\/jats:italic>\n            = 1), 6\/9, (\n            <jats:italic>n<\/jats:italic>\n            = 2), and 9 (\n            <jats:italic>n<\/jats:italic>\n            = 3) were obtained within a 5-month period from a human immunodeficiency virus-negative patient treated for tuberculosis. The isolates were identified with\n            <jats:italic>Pvu<\/jats:italic>\n            II restriction fragment length polymorphism (RFLP) analysis as a single IS\n            <jats:italic>1311<\/jats:italic>\n            RFLP type and six different IS\n            <jats:italic>1245<\/jats:italic>\n            RFLP types. Six separate colonies\/clones obtained by subculture from each of the six isolates were tested for MICs of a set of 10 drugs. This report documents the appearance of isolates that are resistant to antimycobacterial drugs as the duration of therapy increases. Because isolates recovered from the patient following longer duration of treatment were more likely to be resistant to more antimycobacterial drugs, we would conclude that there was selection for antimycobacterial drug-resistant isolates. Analyses of all 36 clones identified three IS\n            <jats:italic>1311<\/jats:italic>\n            and 22 IS\n            <jats:italic>1245<\/jats:italic>\n            types forming three clusters. Tests of 105 environmental samples collected in the home and the work place of the patient yielded 16 mycobacterial isolates, of which one\n            <jats:italic>M. avium<\/jats:italic>\n            from soil was of genotype\n            <jats:italic>dnaJ<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            IS\n            <jats:italic>901<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            IS\n            <jats:italic>1311<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            IS\n            <jats:italic>1245<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            and serotype 2, and the second\n            <jats:italic>M. avium<\/jats:italic>\n            from a vacuum cleaner was of genotype\n            <jats:italic>dnaJ<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            IS\n            <jats:italic>901<\/jats:italic>\n            <jats:sup>\u2212<\/jats:sup>\n            IS\n            <jats:italic>1311<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            IS\n            <jats:italic>1245<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            and serotype 9. Overall analyses of the results did not reveal any relation between serotype, RFLP type, and drug susceptibility. Based on the course of the disease in the patient and different serotypes, IS\n            <jats:italic>1311<\/jats:italic>\n            and IS\n            <jats:italic>1245<\/jats:italic>\n            RFLP types of isolates of\n            <jats:italic>M. avium<\/jats:italic>\n            we suppose represent polyclonal infection.\n          <\/jats:p>","DOI":"10.1128\/jcm.40.10.3712-3719.2002","type":"journal-article","created":{"date-parts":[[2002,9,28]],"date-time":"2002-09-28T00:04:10Z","timestamp":1033171450000},"page":"3712-3719","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["IS\n            <i>1311<\/i>\n            and IS\n            <i>1245<\/i>\n            Restriction Fragment Length Polymorphism Analyses, Serotypes, and Drug Susceptibilities of\n            <i>Mycobacterium avium<\/i>\n            Complex Isolates Obtained from a Human Immunodeficiency Virus-Negative Patient"],"prefix":"10.1128","volume":"40","author":[{"given":"Lenka","family":"Dvorska","sequence":"first","affiliation":[{"name":"Veterinary Research Institute, Brno"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Bartos","sequence":"additional","affiliation":[{"name":"Veterinary Research Institute, Brno"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oldrich","family":"Ostadal","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergology, Faculty Hospital, Olomouc"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarmila","family":"Kaustova","sequence":"additional","affiliation":[{"name":"Department of Diagnostic of Mycobacteria, Regional Institute of Hygiene, Ostrava, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmila","family":"Matlova","sequence":"additional","affiliation":[{"name":"Veterinary Research Institute, Brno"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Pavlik","sequence":"additional","affiliation":[{"name":"Veterinary Research Institute, Brno"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"20","volume":"47","year":"1998","unstructured":"Bartu, V. 1998. 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