{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T16:50:14Z","timestamp":1758991814211},"reference-count":18,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Transmission of\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            between children and their parents was evaluated in 29 pairs from 25 families. The serotypes of 35 pneumococcal isolates from 18 (62.1%) of 29 child-parent pairs were identical. Of the 35 isolates, 23 showed intermediate resistance and 10 were fully resistant to penicillin G. PCR indicated that all 35 strains had at least one alteration in penicillin-binding protein genes\n            <jats:italic>pbp1a<\/jats:italic>\n            ,\n            <jats:italic>pbp2x<\/jats:italic>\n            , and\n            <jats:italic>pbp2b<\/jats:italic>\n            and 33 strains had macrolide resistance genes\n            <jats:italic>mef<\/jats:italic>\n            (A) and\/or\n            <jats:italic>erm<\/jats:italic>\n            (B). As a result, the PCR patterns of 16 of 18 pairs were identical. Molecular typing by pulsed-field gel electrophoresis showed that 12 pairs were indistinguishable, 3 pairs were closely related, 2 pairs were possibly related, and only one pair was different. Our data indicate the presence of a high rate of transmission of penicillin-resistant\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            between children and their parents.\n          <\/jats:p>","DOI":"10.1128\/jcm.40.11.4357-4359.2002","type":"journal-article","created":{"date-parts":[[2002,10,30]],"date-time":"2002-10-30T20:42:12Z","timestamp":1036010532000},"page":"4357-4359","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["High Rate of Transmission of Penicillin-Resistant\n            <i>Streptococcus pneumoniae<\/i>\n            between Parents and Children"],"prefix":"10.1128","volume":"40","author":[{"given":"Kazuhiko","family":"Hoshino","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rinya","family":"Sugita","sequence":"additional","affiliation":[{"name":"Sugita Otorhinolaryngologic Clinic, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norichika","family":"Asoh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon Angelo","family":"Ntabaguzi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiwao","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Oishi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Nagatake","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/15.1.77"},{"key":"e_1_3_2_3_2","unstructured":"Bartlett R. C. 1974. Medical microbiology: quality cost and clinical relevance p. 24-31. John Wiley & Sons Inc. New York N.Y."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-157-40010"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.4.885"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.6.1832-1838.1999"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/516477"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(01)00063-9"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2001.tb00784.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/15.1.99"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.4.801"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/48.6.915"},{"key":"e_1_3_2_13_2","unstructured":"National Committee for Clinical Laboratory Standards. 1998. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A4. National Committee for Clinical Laboratory Standards Wayne Pa."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.12.3218-3222.1996"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.5.1851-1853.2002"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/514783"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.33.9.2233-2239.1995"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.2.625-629.2000"},{"key":"e_1_3_2_19_2","first-page":"1991","volume":"63","year":"2001","unstructured":"Zimmerman, R. K. 2001. Pneumococcal conjugate vaccine for young children. Am. Fam. Phys.63:1991-1998.","journal-title":"Am. Fam. Phys."}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.40.11.4357-4359.2002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.40.11.4357-4359.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T01:31:40Z","timestamp":1646443900000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.40.11.4357-4359.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1128\/JCM.40.11.4357-4359.2002"],"URL":"https:\/\/doi.org\/10.1128\/jcm.40.11.4357-4359.2002","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]},"assertion":[{"value":"2002-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}