{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T13:07:13Z","timestamp":1774703233115,"version":"3.50.1"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A recent study afforded us the opportunity to collect pre- and post-treatment isolates of\n            <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n            from women who supposedly failed to eradicate the organism when tested 8 to 10 days following treatment with a single, directly observed 250-mg dose of ciprofloxacin. In an attempt to differentiate true treatment failure from reinfection, we determined the ciprofloxacin MICs and performed auxotyping, serotyping, and opa typing of the pre- and post-treatment isolates. Paired isolates of\n            <jats:italic>N. gonorrhoeae<\/jats:italic>\n            were obtained from seven different women, despite susceptibility of the initial isolates to ciprofloxacin. Six of seven patients were infected with gonococcal isolates that differed significantly from their primary isolate. These most probably represent reinfection with a different strain, which could originate from the same partner infected with multiple strains or reinfected with a new strain or from a different partner. The susceptibility to ciprofloxacin of all isolates makes the possibility of multiple strains in the patient unlikely. The diversity of the isolates within the pairs therefore suggests rapid reinfection within the partnerships.\n          <\/jats:p>","DOI":"10.1128\/jcm.40.12.4567-4570.2002","type":"journal-article","created":{"date-parts":[[2002,11,26]],"date-time":"2002-11-26T22:43:39Z","timestamp":1038350619000},"page":"4567-4570","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Typing of\n            <i>Neisseria gonorrhoeae<\/i>\n            Reveals Rapid Reinfection in Rural South Africa"],"prefix":"10.1128","volume":"40","author":[{"given":"Prashini","family":"Moodley","sequence":"first","affiliation":[{"name":"Africa Centre for Health and Population Studies and the Department of Medical Microbiology, Nelson R. Mandela School of Medicine, University of Natal, Durban, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iona M. C.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Microbiology, Faculty of Medicine, Imperial College, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A.","family":"Ison","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Microbiology, Faculty of Medicine, Imperial College, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Willem","family":"Sturm","sequence":"additional","affiliation":[{"name":"Africa Centre for Health and Population Studies and the Department of Medical Microbiology, Nelson R. Mandela School of Medicine, University of Natal, Durban, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-16-3-295"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.75.1.3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.76.6.419"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/150.1.44"},{"key":"e_1_3_2_6_2","first-page":"95","volume":"95","year":"1993","unstructured":"Laga, M., A. Manoka, M. Kivuvu, B. Malele, M. Tuliza, N. Nzila, J. Goeman, F. Behets, V. Batter, and M. Alary. 1993. Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study. 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The population genetics of the pathogenic Neisseria p.143-160. In S. Baumberg J. P. W. Young E. M. H. Wellington and J. R. Saunders (ed.) The population genetics of bacteria. SGM Symposium 52. Cambridge University Press Cambridge United Kingdom."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.75.1.60"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.12.4430-4438.2000"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03234-7"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-199801000-00005"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.40.12.4567-4570.2002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.40.12.4567-4570.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T01:23:41Z","timestamp":1646443421000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.40.12.4567-4570.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["10.1128\/JCM.40.12.4567-4570.2002"],"URL":"https:\/\/doi.org\/10.1128\/jcm.40.12.4567-4570.2002","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12]]},"assertion":[{"value":"2002-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-09-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}