{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:20:46Z","timestamp":1790000446148,"version":"4.0.1"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Chronic periodontitis is a common infectious disease in the adult population. The etiology is clearly bacterial, and a small number of bacterial species have been consistently associated with periodontitis, including\n            <jats:italic>Bacteroides forsythus<\/jats:italic>\n            and\n            <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n            . Comparatively little attention has been paid to the identification of health-associated and potentially beneficial bacterial species that may reside in the gingival sulcus. The purpose of the present study was to examine the relationship of the presence of\n            <jats:italic>B. forsythus<\/jats:italic>\n            and a newly identified\n            <jats:italic>Bacteroides<\/jats:italic>\n            phylotype, oral clone BU063, to periodontal health status. The study was accomplished with a set of samples that were collected from subjects with periodontitis and healthy controls. These samples had previously been analyzed for the presence of\n            <jats:italic>P. gingivalis<\/jats:italic>\n            . An oral sampling strategy that included every tooth and a PCR-based detection method were used to maximize detection sensitivity. The presence of\n            <jats:italic>B. forsythus<\/jats:italic>\n            in the oral cavity was strongly associated with periodontitis, and its nearest genetic neighbor, oral clone BU063, was associated with oral health (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.0001 for both). Colonization with\n            <jats:italic>P. gingivalis<\/jats:italic>\n            was independent of the presence of either\n            <jats:italic>Bacteroides<\/jats:italic>\n            species, but the two\n            <jats:italic>Bacteroides<\/jats:italic>\n            species were found together less often than would be expected by chance (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.0001). This suggests the presence of a specific exclusionary mechanism between the two\n            <jats:italic>Bacteroides<\/jats:italic>\n            species. Comparisons between these two organisms may prove useful for studies that determine how\n            <jats:italic>B<\/jats:italic>\n            .\n            <jats:italic>forsythus<\/jats:italic>\n            functions in the disease process. In addition, oral clone BU063 deserves further study as a possible preventive or therapeutic intervention for periodontitis.\n          <\/jats:p>","DOI":"10.1128\/jcm.40.3.821-825.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:58:35Z","timestamp":1027763915000},"page":"821-825","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":63,"title":["Association of\n            <i>Bacteroides forsythus<\/i>\n            and a Novel\n            <i>Bacteroides<\/i>\n            Phylotype with Periodontitis"],"prefix":"10.1128","volume":"40","author":[{"given":"Eugene J.","family":"Leys","sequence":"first","affiliation":[{"name":"Department of Oral Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon R.","family":"Lyons","sequence":"additional","affiliation":[{"name":"Department of Oral Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin L.","family":"Moeschberger","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Biometrics, School of Public Health, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Rumpf","sequence":"additional","affiliation":[{"name":"Department of Oral Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann L.","family":"Griffen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, College of Dentistry"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/320518"},{"key":"e_1_3_2_3_2","first-page":"935","volume":"67","year":"1996","unstructured":"American Academy of Periodontology. 1996. 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