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Genetic differentiation was found between distant hospitals (located in Montpellier and Paris, France) but not for other parameters (anatomic origins or human immunodeficiency virus-positive [HIV<jats:sup>+<\/jats:sup>] and HIV<jats:sup>\u2212<\/jats:sup>patients). Strong nonrandom association between loci could be seen. Such statistical linkages were confirmed upon comparing the patterns of 14 RAPD [random(ly) amplified polymorphic DNA] primers from 20 of these strains to results obtained from multilocus enzyme electrophoresis analysis. This finding suggests a mainly clonal mode of reproduction of<jats:italic>C. glabrata<\/jats:italic>. The consequences of the clonality displayed by<jats:italic>C. glabrata<\/jats:italic>populations on the epidemiology of this yeast are also discussed.<\/jats:p>","DOI":"10.1128\/jcm.40.6.2199-2206.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:09:29Z","timestamp":1027764569000},"page":"2199-2206","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Genetic Structure of<i>Candida glabrata<\/i>Populations in AIDS and Non-AIDS Patients"],"prefix":"10.1128","volume":"40","author":[{"given":"T.","family":"de Meeu\u0302s","sequence":"first","affiliation":[{"name":"Centre d'E\u0301tude du Polymorphisme des Microorganismes, UMR 9926 CNRS-IRD, 34000 Montpellier Cedex 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Renaud","sequence":"additional","affiliation":[{"name":"Centre d'E\u0301tude du Polymorphisme des Microorganismes, UMR 9926 CNRS-IRD, 34000 Montpellier Cedex 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mouveroux","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunologie et de Parasitologie, Faculte\u0301 de Pharmacie, 34060 Montpellier Cedex 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Reynes","sequence":"additional","affiliation":[{"name":"Clinique des Maladies Infectieuses A, Ho\u0302pital Gui de Chauliac, 34000 Montpellier"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Galeazzi","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Parasitologie-Mycologie, Ho\u0302pital Louis Mourier, 92700 Colombes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mallie\u0301","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunologie et de Parasitologie, Faculte\u0301 de Pharmacie, 34060 Montpellier Cedex 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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