{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:43:29Z","timestamp":1791909809432,"version":"4.3.4"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2002,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n We determined the frequencies of antibodies to\n Anaplasma phagocytophila<\/jats:italic>\n , the agent of human granulocytic ehrlichiosis (HGE), in different groups of adults and children from Westchester County, New York. The groups included 159 adult blood donors and 215 children who were seronegative for\n Borrelia burgdorferi<\/jats:italic>\n antibodies, 118 adult patients and 57 children who were seropositive for\n B. burgdorferi<\/jats:italic>\n antibodies, and 42 adult patients with culture-confirmed erythema migrans. Eighteen (11.3%) of the blood donors and 11 (5.1%) of the\n B. burgdorferi<\/jats:italic>\n -seronegative children were found to have\n A. phagocytophila<\/jats:italic>\n antibodies by indirect immunofluorescent-antibody assay (IFA). Nine of 42 (21.4%) patients with culture-confirmed erythema migrans tested at the baseline visit, 42 of 118 (35.6%) adults, and 3 of 57 (5.3%) children whose sera were reactive for\n B. burgdorferi<\/jats:italic>\n antibodies also tested positive for\n A. phagocytophila<\/jats:italic>\n antibodies. The geometric mean titer ranged from 219 to 315 for all groups, and the differences in titers among the groups were not statistically significant. Only one-third of the healthy blood donors reactive by IFA were confirmed to be positive by immunoblotting. We conclude that a significant proportion of adults and children without clinical evidence of HGE will test positive for\n A. phagocytophila<\/jats:italic>\n antibodies when the conventional cutoff titer of 80 is used in the IFA. This information must be considered in interpretation of test results.\n <\/jats:p>","DOI":"10.1128\/jcm.40.7.2612-2615.2002","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:07:23Z","timestamp":1027897643000},"page":"2612-2615","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":92,"title":["Seroprevalence of Antibodies That React with\n Anaplasma phagocytophila<\/i>\n , the Agent of Human Granulocytic Ehrlichiosis, in Different Populations in Westchester County, New York"],"prefix":"10.1128","volume":"40","author":[{"given":"Maria E.","family":"Aguero-Rosenfeld","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine,"},{"name":"Department of Pathology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Donnarumma","sequence":"additional","affiliation":[{"name":"Westchester Medical Center, Valhalla, New York 10595"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois","family":"Zentmaier","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jobby","family":"Jacob","sequence":"additional","affiliation":[{"name":"Westchester Medical Center, Valhalla, New York 10595"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Noto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Carbonaro","sequence":"additional","affiliation":[{"name":"Westchester Medical Center, Valhalla, New York 10595"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary P.","family":"Wormser","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-11-199612010-00006"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.1.1-9.1996"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.2.635-638.2000"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/516529"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03520030054028"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/515048"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530270039029"},{"key":"e_1_3_2_9_2","first-page":"5.","volume":"48","year":"2001","unstructured":"Centers for Disease Control and Prevention. 2001. Summary of notifiable diseases\u2014United States, 1999. Morb. Mortal. Wkly. Rep.48:5.","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"e_1_3_2_10_2","first-page":"842","volume":"112","year":"2000","unstructured":"Cizman, M., T. Avsic-Zupanc, M. Petrovec, E. Ruzic-Sabljic, and M. Pokorn. 2000. Seroprevalence of ehrlichiosis, Lyme borreliosis and tick-borne encephalitis infections in children and young adults in Slovenia. Wien Klin. Wochenschr.112:842-845.","journal-title":"Wien Klin. Wochenschr."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.5.1098-1103.1995"},{"key":"e_1_3_2_12_2","first-page":"2145","year":"2001","unstructured":"Dumler, J. S., A. F. Barbet, C. P. J. Bekker, G. A. Dasch, G. H. Palmer, S. C. Ray, Y. Rikihisa, and F. R. Rurangirwa. 2001. Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, designation of six new species combinations and designation of Ehrlichia equi and \u201cHGE agent\u201d as subjective synonyms of Ehrlichia phagocytophila. Int. J. Evol. Microbiol. 51:2145-2165.","journal-title":"Int. J. E"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.4.1007"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.40.7.2612-2615.2002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.40.7.2612-2615.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T01:45:00Z","timestamp":1646444700000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.40.7.2612-2615.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2002,7]]}},"alternative-id":["10.1128\/JCM.40.7.2612-2615.2002"],"URL":"https:\/\/doi.org\/10.1128\/jcm.40.7.2612-2615.2002","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7]]},"assertion":[{"value":"2002-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-04-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}