{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:32:09Z","timestamp":1787016729670,"version":"build-2736575974"},"reference-count":31,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In vitro, terbinafine is highly active against a broad spectrum of pathogenic fungi. We evaluated the activities of terbinafine and itraconazole against 31 isolates of\n                    <jats:italic>Paracoccidioides brasiliensis.<\/jats:italic>\n                    The tests were conducted by using a broth macrodilution procedure. MICs, in micrograms per milliliter, were as follows: terbinafine, 0.015 to 1.0 (geometric mean, 0.1188); itraconazole, 0.007 to 0.5 (geometric mean, 0.03165). The usual therapy for paracoccidioidomycosis is sulfonamides, amphotericin B, and azole derivatives (ketoconazole, itraconazole, and fluconazole). In comparison to amphotericin B, azole derivatives allow shorter treatment courses, can be administered orally, and are equally effective. Itraconazole has as high efficacy as ketoconazole, but with superior tolerance. It is the current drug of choice for treatment of paracoccidioidomycosis. The data obtained in this study indicate that terbinafine is active against\n                    <jats:italic>P. brasiliensis<\/jats:italic>\n                    in vitro and suggest that this allylamine can be considered a new option as drug therapy for paracoccidioidomycosis.\n                  <\/jats:p>","DOI":"10.1128\/jcm.40.8.2828-2831.2002","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T15:36:19Z","timestamp":1033486579000},"page":"2828-2831","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["In Vitro Comparison of Activities of Terbinafine and Itraconazole against\n                    <i>Paracoccidioides brasiliensis<\/i>"],"prefix":"10.1128","volume":"40","author":[{"given":"R. C.","family":"Hahn","sequence":"first","affiliation":[{"name":"Department of Microbiology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J. F.","family":"Fontes","sequence":"additional","affiliation":[{"name":"Nu\u0301cleo de Estudos de Doenc\u0327as Infecciosas e Tropicais, TRO\u0301PICA, Faculdade de Cie\u0302ncias Me\u0301dicas, Universidade Federal de Mato Grosso, Cuiaba, Mato Grosso, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. D.","family":"Batista","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Hamdan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.6.2.89"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/09546639809160687"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.4.848-852.1996"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.6.1089-1094.1991"},{"key":"e_1_3_2_6_2","first-page":"197","volume":"18","year":"1955","unstructured":"Fava Netto, C. 1955. Estudos quantitativos sobre a fixa\u00e7\u00e3o do complemento na blastomicose Sul Americana com ant\u00edgeno polissacar\u00eddico. Arq. Cir. Clin. Exp.18:197-254.","journal-title":"Arq. Cir. Clin. 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