{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:25:08Z","timestamp":1759335908987},"reference-count":13,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Clostridium difficile<\/jats:italic>\n            , the most common cause of antibiotic-associated diarrhea, is occasionally isolated from extraintestinal sites and is usually found as part of a polymicrobial flora. We report a case of brain empyema that occurred after the recurrent intestinal carriage of a nontoxigenic strain of\n            <jats:italic>C. difficile<\/jats:italic>\n            . Brain abscess cultures contained both toxigenic and nontoxigenic isolates. Pulsed-field gel electrophoresis showed that nontoxigenic isolates from the intestine and from the brain were identical.\n          <\/jats:p>","DOI":"10.1128\/jcm.41.1.509-511.2003","type":"journal-article","created":{"date-parts":[[2003,1,7]],"date-time":"2003-01-07T18:03:11Z","timestamp":1041962591000},"page":"509-511","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["<i>Clostridium difficile<\/i>\n            Brain Empyema after Prolonged Intestinal Carriage"],"prefix":"10.1128","volume":"41","author":[{"given":"J.","family":"Gravisse","sequence":"first","affiliation":[{"name":"Service of Bacteriology-Virology, Lariboisie\u0300re Hospital, Assistance Publique-Ho\u0302pitaux de Paris, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Barnaud","sequence":"additional","affiliation":[{"name":"Service of Bacteriology-Virology, Lariboisie\u0300re Hospital, Assistance Publique-Ho\u0302pitaux de Paris, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Hanau-Berc\u0327ot","sequence":"additional","affiliation":[{"name":"Service of Bacteriology-Virology, Lariboisie\u0300re Hospital, Assistance Publique-Ho\u0302pitaux de Paris, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Raskine","sequence":"additional","affiliation":[{"name":"Service of Bacteriology-Virology, Lariboisie\u0300re Hospital, Assistance Publique-Ho\u0302pitaux de Paris, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Riahi","sequence":"additional","affiliation":[{"name":"Service of Bacteriology-Virology, Lariboisie\u0300re Hospital, Assistance Publique-Ho\u0302pitaux de Paris, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Gaillard","sequence":"additional","affiliation":[{"name":"Service of Bacteriology-Virology, Raymond Poincarre\u0301 Hospital, Assistance Publique-Ho\u0302pitaux de Paris, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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