{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:16:33Z","timestamp":1789452993547,"version":"build-2803163510"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Campylobacter jejuni<\/jats:italic>\n            isolates (\n            <jats:italic>n<\/jats:italic>\n            = 234) associated with gastroenteritis and the Guillain-Barre\u0301 syndrome (GBS) in the island of Curac\u0327ao, Netherlands Antilles, and collected from March 1999 to March 2000 were investigated by a range of molecular typing techniques. Data obtained by pulsed-field gel electrophoresis (PFGE), amplified fragment length polymorphism (AFLP) analysis, multilocus sequence typing (MLST), automated ribotyping, and sequence analysis of the short variable region of the flagellin gene (\n            <jats:italic>flaA<\/jats:italic>\n            ) were analyzed separately and in combination. Similar groupings were obtained by all methods, with the data obtained by MLST and AFLP analysis exhibiting the highest degree of congruency. MLST identified 29 sequence types, which were assigned to 10 major clonal complexes. PFGE, AFLP analysis, and ribotyping identified 10, 9, and 8 of these clonal groups, respectively; however, these three techniques permitted subdivision of the clonal groups into more different types. Members of seven clonal groups comprising 107 isolates were obtained from November 1999 to February 2000, and no distinguishing characteristics were identified for two GBS-associated strains. The sequence type 41 (ST-41), ST-508, and ST-657 clonal complexes and their corresponding AFLP types have been rare or absent in the\n            <jats:italic>Campylobacter<\/jats:italic>\n            data sets described to date. We conclude that several clonal complexes of\n            <jats:italic>C. jejuni<\/jats:italic>\n            are associated with human disease in Curac\u0327ao, and some of these have not been reported elsewhere. Furthermore, given the observation that\n            <jats:italic>C. jejuni<\/jats:italic>\n            -associated diseases appear to be more severe from November to February, it can be speculated that this may be due to the presence of virulent clones with a limited span of circulation.\n          <\/jats:p>","DOI":"10.1128\/jcm.41.12.5593-5597.2003","type":"journal-article","created":{"date-parts":[[2003,12,8]],"date-time":"2003-12-08T23:38:01Z","timestamp":1070926681000},"page":"5593-5597","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":51,"title":["Molecular Evidence for Dissemination of Unique\n            <i>Campylobacter jejuni<\/i>\n            Clones in Curac\u0327ao, Netherlands Antilles"],"prefix":"10.1128","volume":"41","author":[{"given":"Birgitta","family":"Duim","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Academic Medical Center, Amsterdam"},{"name":"Animal Sciences Group (ID-Lelystad), Lelystad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy C. R.","family":"Godschalk","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology &amp; Infectious Diseases, Erasmus MC, Rotterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"van den Braak","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology &amp; Infectious Diseases, Erasmus MC, Rotterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate E.","family":"Dingle","sequence":"additional","affiliation":[{"name":"The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen R.","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"Animal Sciences Group (ID-Lelystad), Lelystad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewald","family":"Leyde","sequence":"additional","affiliation":[{"name":"Analytic Diagnostic Center, Curac\u0327ao, Netherlands Antilles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"van der Plas","sequence":"additional","affiliation":[{"name":"TNO Voeding, Voedingsmiddelenmicrobiologie, Zeist, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances M.","family":"Colles","sequence":"additional","affiliation":[{"name":"The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert P.","family":"Endtz","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology &amp; Infectious Diseases, Erasmus MC, Rotterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap A.","family":"Wagenaar","sequence":"additional","affiliation":[{"name":"Animal Sciences Group (ID-Lelystad), Lelystad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin C. J.","family":"Maiden","sequence":"additional","affiliation":[{"name":"The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"van Belkum","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology &amp; Infectious Diseases, Erasmus MC, Rotterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0501.990104"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0809.02-0122"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.1.14-23.2001"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.9.3346-3349.2001"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.66.9.3917-3923.2000"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.65.6.2369-2375.1999"},{"key":"e_1_3_1_8_2","first-page":"2297","volume":"38","year":"1999","unstructured":"Endtz, H. P., C. W. Ang, N. Van Den Braak, B. Duim, L. J. Price, A. Rigter, D. L. Woodward, F. G. Rodgers, W. M. Johnson, J. A. Wagenaar, B. A. Jacobs, H. A. Verbrugh, and A. Van Belkum. 1999. Molecular characterization of Campylobacter jejuni from patients with Guillain-Barr\u00e9 and Miller Fisher syndrome. J. Clin. Microbiol.38:2297-2301.","journal-title":"J. Clin. Microbiol."},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.2.265-269.1996"},{"key":"e_1_3_1_10_2","unstructured":"Friedman C. J. J. Neimann H. C. Wegener and R. V. Tauxe. 2000. Epidemiology of Campylobacter jejuni infections in the United States and other industrialized nations p. 121-138. In I. Nachamkin and M. Blaser (ed.) Campylobacter . 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Epidemiology of Campylobacter jejuni infections in the United States and other industrialized coutries p. 9-19. In I. Nachamkin M. J. Blaser and L. S. Tompkins (ed.) Campylobacter jejuni : current status and future trends. American Society for Microbiology Washington D.C."},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.4.978-981.1997"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.11.1467"},{"key":"e_1_3_1_24_2","first-page":"503","volume":"92","year":"2002","unstructured":"Wareing, D. R., F. E. Bolton, A. J. Fox, P. A. Wright, and D. L. Greenway. 2002. Phenotypic diversity of Campylobacter isolates from sporadic cases of human enteritis in the UK. J. Appl. Microbiol.92:503-509.","journal-title":"J. Appl. 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