{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:02:03Z","timestamp":1788580923653,"version":"build-2803163510"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Direct heteroduplex analysis and a universal heteroduplex generator assay were performed to detect rifampin resistance rapidly in Turkish\n            <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n            isolates. Cross-resistance to rifapentine, rifabutin, and rifalazil was investigated. A relationship between specific mutations and resistance patterns, which can guide the choice of an appropriate therapeutic regimen for tuberculosis patients, was identified.\n          <\/jats:p>","DOI":"10.1128\/jcm.41.2.816-818.2003","type":"journal-article","created":{"date-parts":[[2003,2,6]],"date-time":"2003-02-06T20:03:31Z","timestamp":1044561811000},"page":"816-818","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Rapid Detection of Rifampin Resistance in\n            <i>Mycobacterium tuberculosis<\/i>\n            Isolates by Heteroduplex Analysis and Determination of Rifamycin Cross-Resistance in Rifampin-Resistant Isolates"],"prefix":"10.1128","volume":"41","author":[{"given":"Zeynep","family":"Sar\u0131bas\u0327","sequence":"first","affiliation":[{"name":"Department of Microbiology and Clinical Microbiology, Hacettepe University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan\u0131l","family":"Kocago\u0308z","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Clinical Microbiology, Hacettepe University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpaslan","family":"Alp","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Clinical Microbiology, Hacettepe University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayfer","family":"Gu\u0308nalp","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Clinical Microbiology, Hacettepe University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(93)90060-S"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.1.25"},{"key":"e_1_3_2_4_2","unstructured":"Heifets L. B. 1991. Drug susceptibility tests in the management of chemotherapy of tuberculosis p. 89-120. In L. B. Heifets (ed.) Drug susceptibility in the chemotherapy of mycobacterial infections. CRC Press Boca Raton Fla."},{"key":"e_1_3_2_5_2","unstructured":"Inderlied C. B. 1991. Antimycobacterial agents: In vitro susceptibility testing spectrums of activity mechanisms of action and resistance and assays for activity in biological fluids p. 134-197. In V. Lorian (ed.) Antibiotics in laboratory medicine 3rd ed. Williams & Wilkins Baltimore Md."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.6.1435-1438.1993"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.11.2655"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1054\/tuld.1998.0002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90417-F"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.10.2380"},{"key":"e_1_3_2_11_2","unstructured":"Williams D. L. C. W. Limbers L. Spring S. Jayachandra and T. P. Gillis. 1996. PCR-heteroduplex detection of rifampin-resistant Mycobacterium tuberculosis p. 122-129. In D. H. Persing (ed.) PCR protocols for emerging infectious diseases. A supplement to Diagnostic molecular microbiology: principles and applications. American Society for Microbiology Washington D.C."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.7.1853"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/516313"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150170143"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/42.5.621"},{"key":"e_1_3_2_16_2","unstructured":"Yap E. P. H. and J. O. McGee. 1994. Detection of mutations by PCR p. 107-120. In H. G. Griffin and A. M. Griffin (ed.) PCR technology. Current innovations. CRC Press Boca Raton Fla."}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.41.2.816-818.2003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.41.2.816-818.2003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T02:20:27Z","timestamp":1646446827000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.41.2.816-818.2003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["10.1128\/JCM.41.2.816-818.2003"],"URL":"https:\/\/doi.org\/10.1128\/jcm.41.2.816-818.2003","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,2]]},"assertion":[{"value":"2002-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-11-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}