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To measure pathogenicity, the odds ratio for diarrhea, adjusted for age, sex, and coinfections with other enteropathogens, was determined by logistic regression. Standard estimation of the population attributable risk indicated that rotavirus, enterotoxigenic<jats:italic>Escherichia coli<\/jats:italic>that produced only the heat-stable toxin ST,<jats:italic>Isospora<\/jats:italic>spp.,<jats:italic>Cryptosporidium parvum<\/jats:italic>, Shiga toxin (Stx)-producing<jats:italic>E. coli<\/jats:italic>(STEC), and<jats:italic>Shigella<\/jats:italic>spp. or enteroinvasive<jats:italic>E. coli<\/jats:italic>were the most important contributors to diarrhea in this population. Stx2- but not Stx1-producing STEC strains were pathogenic. Enteroaggregative<jats:italic>E. coli<\/jats:italic>, diffusely adherent<jats:italic>E. coli<\/jats:italic>, and attaching-and-effacing<jats:italic>E. coli<\/jats:italic>strains, which were the most commonly isolated microorganisms, were not associated with diarrhea. For most of the microorganisms, primary infections did not confer protection against reinfection with the same organism, but some conferred protection against diarrhea from reinfection.<\/jats:p>","DOI":"10.1128\/jcm.41.9.4238-4245.2003","type":"journal-article","created":{"date-parts":[[2003,9,4]],"date-time":"2003-09-04T18:34:38Z","timestamp":1062700478000},"page":"4238-4245","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":78,"title":["Cohort Study of Guinean Children: Incidence, Pathogenicity, Conferred Protection, and Attributable Risk for Enteropathogens during the First 2 Years of Life"],"prefix":"10.1128","volume":"41","author":[{"given":"Palle","family":"Valentiner-Branth","sequence":"first","affiliation":[{"name":"Bandim Health Project"},{"name":"Department of Epidemiology Research, Danish Epidemiology Science Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Steinsland","sequence":"additional","affiliation":[{"name":"The National Public Health Laboratory, Bissau, Guinea-Bissau"},{"name":"Centre for International Health, University of Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thea K.","family":"Fischer","sequence":"additional","affiliation":[{"name":"The National Public Health Laboratory, Bissau, Guinea-Bissau"},{"name":"Department of Epidemiology Research, Danish Epidemiology Science Centre"},{"name":"Centre for International Health, University of Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Perch","sequence":"additional","affiliation":[{"name":"Bandim Health Project"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemming","family":"Scheutz","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Infections and Parasitology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Dias","sequence":"additional","affiliation":[{"name":"The National Public Health Laboratory, Bissau, Guinea-Bissau"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Aaby","sequence":"additional","affiliation":[{"name":"Bandim Health Project"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka\u030are","family":"M\u00f8lbak","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research, Danish Epidemiology Science Centre"},{"name":"Department of Epidemiology, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halvor","family":"Sommerfelt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research, Danish Epidemiology Science Centre"},{"name":"Centre for International Health, University of Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1992.tb03976.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/314593"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.4.973-977.1995"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.23.6.545"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","unstructured":"Andersen P. 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