{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T01:59:54Z","timestamp":1794275994271,"version":"4.9.0"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Bartonella henselae<\/jats:italic>\n            is the major etiological agent of cat scratch disease in humans. Cats act as the natural reservoir of\n            <jats:italic>B. henselae<\/jats:italic>\n            and can transmit the infection to humans by a bite or scratch. The prevalence of\n            <jats:italic>B. henselae<\/jats:italic>\n            in cat populations was evaluated by serological and bacteriological tests. A total of 769 stray cats from three urban and three rural areas in northern Italy were sampled between January 1999 and December 2000. The positive and the negative predictive values of serological tests with respect to bacteremic status were evaluated. Tests of a total of 140 cats (18%) resulted in detection of bacteremia. A total of 540 cats were tested by serology; 207 (38%) were seropositive. Of the 531 cats tested by both methods, the results for 65 (12.2%) showed both bacteremia detection and seropositivity. The molecular typing of the isolates showed that 20.6% of bacteremic cats were infected with\n            <jats:italic>B. henselae<\/jats:italic>\n            type I strain, 61.1% were infected with\n            <jats:italic>B. henselae<\/jats:italic>\n            type II, and 18.3% were coinfected with both. A statistically significant difference in antibody and bacteremia prevalences among geographical areas was detected. Statistical analysis showed no association between characteristics such as seroprevalence-bacteremic status, sex, general health status, and the presence of ectoparasites. The negative predictive value of serological test was 84.7%, and the positive predictive value was 31.8%. Receiving operator characteristic analysis of the data showed that serological tests had a low predictive value in relation to the bacteremic status of a cat; in surveys aimed at assessing the real risk of\n            <jats:italic>B. henselae<\/jats:italic>\n            infection in a human population, therefore, we suggest the use of blood culture as the reference test. Nevertheless, both blood culture assays and serological tests for\n            <jats:italic>Bartonella<\/jats:italic>\n            infection should be performed for a complete evaluation of the health status of cats.\n          <\/jats:p>","DOI":"10.1128\/jcm.42.1.264-268.2004","type":"journal-article","created":{"date-parts":[[2004,1,10]],"date-time":"2004-01-10T18:17:42Z","timestamp":1073758662000},"page":"264-268","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":43,"title":["Prevalence of\n            <i>Bartonella henselae<\/i>\n            in Italian Stray Cats: Evaluation of Serology To Assess the Risk of Transmission of\n            <i>Bartonella<\/i>\n            to Humans"],"prefix":"10.1128","volume":"42","author":[{"given":"Massimo","family":"Fabbi","sequence":"first","affiliation":[{"name":"Sezione Diagnostica di Pavia, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna \u201cBruno Ubertini,\u201d 27100 Pavia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"De Giuli","sequence":"additional","affiliation":[{"name":"Sezione Diagnostica di Pavia, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna \u201cBruno Ubertini,\u201d 27100 Pavia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Tranquillo","sequence":"additional","affiliation":[{"name":"Osservatorio Epidemiologico Veterinario Regionale, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna \u201cBruno Ubertini,\u201d 25124 Brescia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roldano","family":"Bragoni","sequence":"additional","affiliation":[{"name":"Sezione Diagnostica di Pavia, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna \u201cBruno Ubertini,\u201d 27100 Pavia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Casiraghi","sequence":"additional","affiliation":[{"name":"Dipartimento di Patologia Animale, Igiene e Sanita\u0300 Pubblica Veterinaria Universita\u0300 degli studi di Milano, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Genchi","sequence":"additional","affiliation":[{"name":"Dipartimento di Patologia Animale, Igiene e Sanita\u0300 Pubblica Veterinaria Universita\u0300 degli studi di Milano, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.2.743-746.2001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.9.2256-2261.1997"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.2.254-260.1996"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.4.1221-1226.2001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.20506\/rst.19.1.1204"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.9.2445-2450.1995"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.8.1952-1956.1996"},{"key":"e_1_3_2_9_2","first-page":"76","volume":"66","year":"1950","unstructured":"Debr\u00e8, R., M. 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Immunopathol."}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.42.1.264-268.2004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.42.1.264-268.2004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T13:04:28Z","timestamp":1646485468000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.42.1.264-268.2004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1128\/JCM.42.1.264-268.2004"],"URL":"https:\/\/doi.org\/10.1128\/jcm.42.1.264-268.2004","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"2003-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-10-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}