{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:25:53Z","timestamp":1791199553395,"version":"4.2.0"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The availability of the\n            <jats:italic>Tropheryma whipplei<\/jats:italic>\n            genome offers the putative possibility of choosing logical DNA targets. We applied a PCR assay (targeting repeated sequences of\n            <jats:italic>T. whipplei<\/jats:italic>\n            ) to samples from patients with Whipple's disease and to those from members of a control group. When compared to the results seen with regular PCR, the sensitivity of repeat PCR was significantly enhanced (\n            <jats:italic>P<\/jats:italic>\n            = 0.02) without alteration of its specificity.\n          <\/jats:p>","DOI":"10.1128\/jcm.42.1.401-403.2004","type":"journal-article","created":{"date-parts":[[2004,1,10]],"date-time":"2004-01-10T18:17:42Z","timestamp":1073758662000},"page":"401-403","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":92,"title":["Use of Genome Selected Repeated Sequences Increases the Sensitivity of PCR Detection of\n            <i>Tropheryma whipplei<\/i>"],"prefix":"10.1128","volume":"42","author":[{"given":"Florence","family":"Fenollar","sequence":"first","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020, IFR 48, Faculte\u0301 de me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, 13385 Marseille cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Edouard","family":"Fournier","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020, IFR 48, Faculte\u0301 de me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, 13385 Marseille cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Robert","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020, IFR 48, Faculte\u0301 de me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, 13385 Marseille cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020, IFR 48, Faculte\u0301 de me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, 13385 Marseille cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"1495","volume":"126","year":"1996","unstructured":"Altwegg, M., A. 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