{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:12:15Z","timestamp":1791141135919,"version":"4.1.0"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Over a 4-month period from November 2002 to February 2003, 27 ceftazidime-resistant or cefotaxime-resistant nonrepetitive\n            <jats:italic>Enterobacter cloacae<\/jats:italic>\n            isolates were collected from 27 patients hospitalized at HuaShan Hospital, Shanghai, People's Republic of China. The Etest did not detect extended-spectrum beta-lactamases (ESBLs) in those 27 isolates; however, screening by the NCCLS ESBL disk test and confirmatory tests detected ESBLs in 4 of 27 isolates and PCR detected ESBLs in 23 of 27 isolates. The majority of ESBL producers exhibited the same repetitive extragenic palindromic PCR pattern but harbored different ESBL genes. CTX-M-3 was the most prevalent ESBL in our study. Interestingly, 12 clonally related\n            <jats:italic>E. cloacae<\/jats:italic>\n            isolates possessed a novel\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>VEB<\/jats:sub>\n            -type beta-lactamase,\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>VEB-3<\/jats:sub>\n            .\n            <jats:italic>Bla<\/jats:italic>\n            <jats:sub>VEB-3<\/jats:sub>\n            was encoded by the chromosome and was located in an integron. Nine of the 12 isolates harbored both the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>VEB-3<\/jats:sub>\n            and the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M-3<\/jats:sub>\n            -like ESBLs. This is the first report of a VEB-1-like ESBL in China and the first report of the simultaneous presence of VEB-1 and CTX-M-3-like ESBLs in an isolate.\n          <\/jats:p>","DOI":"10.1128\/jcm.43.2.826-831.2005","type":"journal-article","created":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T21:42:56Z","timestamp":1107553376000},"page":"826-831","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":66,"title":["Outbreak of Infection Caused by\n            <i>Enterobacter cloacae<\/i>\n            Producing the Novel VEB-3 Beta-Lactamase in China"],"prefix":"10.1128","volume":"43","author":[{"given":"Xiaofei","family":"Jiang","sequence":"first","affiliation":[{"name":"Center of Laboratory Medicine of Huashan Hospital, Shanghai Medical College, Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxing","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Rijin Hospital, Shanghai Second Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory of the Sixth People's Hospital of Shanghai, Shanghai, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyi","family":"Yuan","sequence":"additional","affiliation":[{"name":"Center of Laboratory Medicine of Huashan Hospital, Shanghai Medical College, Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Rijin Hospital, Shanghai Second Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Laboratory Medicine of Huashan Hospital, Shanghai Medical College, Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Center of Laboratory Medicine of Huashan Hospital, Shanghai Medical College, Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Rijin Hospital, Shanghai Second Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Center of Laboratory Medicine of Huashan Hospital, Shanghai Medical College, Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.9.2163-2169.1996"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.4.1237-1243.2002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/38.1.127"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.10.2593-2597.1997"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.5.1791-1796.2000"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/27.4.441"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.3.1016-1022.2000"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.8.2061-2067.1997"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(05)70143-X"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/338786"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.1.175-182.2001"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/36.1.65"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1991.tb00755.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2003.07.004"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.5.703"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1999.tb13691.x"},{"key":"e_1_3_2_18_2","unstructured":"National Committee for Clinical Laboratory Standards. 2002. 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